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1. (WO2012125623) CLEAVAGE INHIBITORS OF TRANSFORMING GROWTH FACTOR BETA TYPE I RECEPTOR AND USES THEREOF IN CANCER THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/125623    International Application No.:    PCT/US2012/028903
Publication Date: 20.09.2012 International Filing Date: 13.03.2012
IPC:
C07K 16/28 (2006.01), A61K 31/00 (2006.01), C07K 14/71 (2006.01), C12Q 1/37 (2006.01), G01N 33/574 (2006.01), A61P 35/04 (2006.01), A61K 39/395 (2006.01)
Applicants: LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. [CH/US]; 666 Third Avenue 28th Floor New York, NY 10017 (US) (For All Designated States Except US).
LANDSTROM, Marene, Inga-britt [SE/SE]; (SE).
MU, Yabing [CN/SE]; (SE).
SUNDAR, Reshma [IN/SE]; (SE).
THAKUR, Noopur [IN/SE]; (SE).
GUDEY, Shyam, Kumar [IN/SE]; (SE).
EKMAN, Maria [SE/SE]; (SE).
HELDIN, Carl-henrik [US/SE]; (SE)
Inventors: LANDSTROM, Marene, Inga-britt; (SE).
MU, Yabing; (SE).
SUNDAR, Reshma; (SE).
THAKUR, Noopur; (SE).
GUDEY, Shyam, Kumar; (SE).
EKMAN, Maria; (SE).
HELDIN, Carl-henrik; (SE)
Agent: VAN AMSTERDAM, John, R.; WOLF, GREENFIELD & SACKS, P.C. 600 Atlantic Avenue Boston, MA 02210-2206 (US)
Priority Data:
61/452,549 14.03.2011 US
Title (EN) CLEAVAGE INHIBITORS OF TRANSFORMING GROWTH FACTOR BETA TYPE I RECEPTOR AND USES THEREOF IN CANCER THERAPY
(FR) INHIBITEURS DE CLIVAGE DU RÉCEPTEUR DE TYPE I DU FACTEUR DE CROISSANCE TRANSFORMANT BÊTA ET SES UTILISATIONS EN THÉRAPIE ANTICANCÉREUSE
Abstract: front page image
(EN)Disclosed herein are methods to inhibit cleavage of a type I receptor of transforming growth factor beta (ΤβRI) and reduce cancer cell invasiveness/metastasis, and agents and pharmaceutical compositions for use in these methods. Also disclosed herein are methods for identifying agents that inhibit cleavage of ΤβRI and methods for diagnosing and/or prognosing cancer based on nuclear localization of a intracellular domain of ΤβRI, which is a product of ΤβRI cleavage.
(FR)La présente invention concerne des procédés d'inhibition du clivage d'un récepteur de type I du facteur de croissance transformant bêta (ΤβRI) et de réduction du caractère invasif/des métastases de cellules cancéreuses, ainsi que des agents et des compositions pharmaceutiques à utiliser dans ces procédés. La présente invention concerne également des procédés d'identification d'agents qui inhibent le clivage de ΤβRI et des méthodes de diagnostic et/ou de pronostic du cancer sur la base de la localisation nucléaire d'un domaine intracellulaire de ΤβRI, qui est un produit du clivage de ΤβRI.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)