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1. (WO2012125544) NECROPTOSIS INHIBITORS AND METHODS OF USE THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/125544    International Application No.:    PCT/US2012/028747
Publication Date: 20.09.2012 International Filing Date: 12.03.2012
IPC:
C07D 487/04 (2006.01), C07D 209/82 (2006.01), C07D 417/12 (2006.01), A61K 31/403 (2006.01), A61P 29/00 (2006.01), A61P 25/00 (2006.01)
Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02138 (US) (For All Designated States Except US).
YUAN, Junying [US/US]; (US) (For US Only)
Inventors: YUAN, Junying; (US)
Agent: SMITH, DeAnn, F.; Patent Group Foley Hoag, LLP 155 Seaport Boulevard Boston, MA 02210-2600 (US)
Priority Data:
61/451,772 11.03.2011 US
Title (EN) NECROPTOSIS INHIBITORS AND METHODS OF USE THEREFOR
(FR) INHIBITEURS DE LA NÉCROPTOSE ET LEURS MÉTHODES D'UTILISATION
Abstract: front page image
(EN)Described herein are compositions that inhibit the production of TNFα downstream of CD40 activation. As such, also described are various methods of using compositions exhibiting this activity for the treatment or prevention of inflammatory diseases associated with TNFα production or CD40 activation.
(FR)La présente invention concerne des compositions inhibant la production de TNFα en aval de l'activation des CD40. L'invention concerne également diverses méthodes d'utilisation de compositions dotées de ladite activité d'inhibition en vue du traitement ou de la prévention de maladies inflammatoires associées à la production de TNFα ou à l'activation des CD40.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)