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1. WO2012125457 - MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME AND DATA MANAGEMENT SYSTEMS AND METHODS

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Claims

1 . A blood filtration device comprising:

a generally cylindrical housing having an interior wall;

an interior member mounted interior of the housing and having an external surface;

the interior wall of the housing and/or the external surface of the interior member including a porous membrane spaced apart from the facing wall of the housing or surface of the interior member so as to define an annular gap therebetween;

the housing and interior member being relatively rotatable;

an inlet for directing whole blood comprising plasma and red cells into the annular gap;

a first outlet for directing plasma passing through the membrane to a collection container; and

a second outlet for directing from the annular gap the remaining blood components;

wherein the membrane has a surface area sufficient to separate plasma at a flow rate resulting in the residence time of red blood cells within the annular gap being insufficient to cause undue hemolysis.

2. The blood filtration device of claim 1 wherein the interior member has a diameter greater than the diameter of the inner member of prior art devices and/or a filtration length of greater than the filtration length of the inner member of a reference device.

3. The blood filtration device of any of the above claims wherein the inner member has a diameter of up to about 2.0 times the diameter of the inner member of the prior art and a filtration length of up to about 2.5 times the filtration length of the inner member of the reference device.

4. The blood filtration device of any of the above claims wherein the rotary spinner has diameter of about 1 .65" and a filtration length of about 5.52".

5. The blood filtration device of any of claims 1 -4 further comprising a ridge extending from one of the interior wall of the housing or the external wall of the interior member so as to reduce the annular gap therebetween, the ridge defining separate flow regions for fluid introduced into the annular gap.

6. A blood filtration device comprising:

a generally cylindrical housing having an interior wall;

an interior member mounted interior of the housing and having an external surface;

the interior wall of the housing and/or the external surface of the interior member including a filter membrane spaced from the facing wall of the housing or surface of the interior member so as to define an annular gap therebetween;

the housing and interior member being relatively rotatable;

a ridge extending from one of the interior wall of the housing or the external surface of the interior member so as to reduce the annular gap therebetween, the ridge defining separate flow regions for fluid introduced into the annular gap.

7. The blood filtration device of claim 5 or 6 wherein the ridge has an axial dimension of at least the size of the annular gap.

8. A method of designing a blood filtration device including a porous membrane, the steps comprising:

developing a model utilizing inputs obtained semi-empirically from an existing filtration device having a porous membrane of a specified dimension to obtain specified outputs;

applying the model to filtration devices of varying dimensions to obtain predicted values for the specified outputs;

reviewing the predicted values obtained for the specified outputs; and selecting a filter membrane surface area based on a comparison of the predicted values obtained by application of the model.

9. The method of claim 8 wherein the selected membrane dimensions provides a membrane surface area that enhances one or more filtration characteristics.

10. The method of claim 9 wherein the filtration device comprises an inner member having the filter membrane mounted thereto, the inner member being mounted for rotation relative to a generally cylindrical housing and spaced therefrom to define a blood recovering gap, the inner member having a diameter and a filtration length sufficient to allow filtration without undue lysis to red blood cells in the blood.

1 1 . The method of claims 8-10 wherein model is applied to filtration devices having varying dimensions for one or more of filtration length, inner radius of the shear gap and the radius of the rotor with the membrane attached.