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1. (WO2012124334) ANTIBODY, PHARMACEUTICAL COMPOSITION USED FOR TREATMENT OF BREAST CANCER, TUMOR TEST METHOD, AND REAGENT FOR TESTING TUMOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/124334    International Application No.:    PCT/JP2012/001802
Publication Date: 20.09.2012 International Filing Date: 14.03.2012
IPC:
C07K 16/28 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01), C12Q 1/68 (2006.01), G01N 33/574 (2006.01), G01N 33/68 (2006.01), C12N 15/09 (2006.01), C12P 21/08 (2006.01)
Applicants: National Institute of Biomedical Innovation [JP/JP]; 7-6-8, Saito-Asagi, Ibaraki-shi, Osaka 5670085 (JP) (For All Designated States Except US).
TSUNODA, Shinichi [JP/JP]; (JP) (For US Only).
NAGANO, Kazuya [JP/JP]; (JP) (For US Only).
TSUTSUMI, Yasuo [JP/JP]; (JP) (For US Only)
Inventors: TSUNODA, Shinichi; (JP).
NAGANO, Kazuya; (JP).
TSUTSUMI, Yasuo; (JP)
Agent: MAEDA & PARTNERS; Osaka-Marubeni Bldg.5F, 5-7, Hommachi 2-chome, Chuo-ku, Osaka-shi, Osaka 5410053 (JP)
Priority Data:
2011-057029 15.03.2011 JP
Title (EN) ANTIBODY, PHARMACEUTICAL COMPOSITION USED FOR TREATMENT OF BREAST CANCER, TUMOR TEST METHOD, AND REAGENT FOR TESTING TUMOR
(FR) ANTICORPS, COMPOSITION PHARMACEUTIQUE UTILISÉS POUR LE TRAITEMENT DU CANCER DU SEIN, PROCÉDÉ DE TEST DE TUMEUR, ET RÉACTIF POUR LE TEST DE TUMEUR
(JA) 抗体、乳がんの治療に用いられる医薬組成物、腫瘍検査方法、及び、腫瘍検査用試薬
Abstract: front page image
(EN)Provided are an antibody and a pharmaceutical composition, both of which are effective for the treatment of breast cancer, particularly a triple-negative case of breast cancer. An antibody capable of binding specifically to a extracellular domain of EphA10 is allowed to act. An example of the extracellular domain is a fibronectin domain. The EphA10 positive ratio is about 67% in a triple-negative case. In a biological sample separated from a living body, EphA10 can be detected as a tumor marker for stomach cancer, prostate cancer or colorectal cancer.
(FR)L'invention concerne un anticorps et une composition pharmaceutique, les deux étant efficaces pour le traitement du cancer du sein, en particulier un cas triple négatif de cancer du sein. L'invention concerne également un anticorps apte à se lier spécifiquement à un domaine extracellulaire de EphA10 pour agir. Un exemple du domaine extracellulaire est un domaine fibronectine. Le rapport positif EphA10 est d'environ 67% dans un cas triple négatif. Dans un échantillon biologique prélevé d'un corps vivant, EphA10 peut être détecté en tant que marqueur de tumeur pour le cancer de l'estomac, le cancer de la prostate ou le cancer colorectal.
(JA) 乳がん、特にトリプルネガティブ症例の治療に有効な抗体及び医薬組成物を提供する。EphA10の細胞外ドメインに特異的に結合する抗体を作用させる。細胞外ドメインは例えばフィブロネクチンドメインである。トリプルネガティブ症例におけるEphA10陽性率は約67%である。また、生体から分離された生体検体について、EphA10を、胃がん、前立腺がん、又は大腸がんの腫瘍マーカーとして検出することができる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)