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1. (WO2012122921) SALT FORM OF HYDROXYPHENYLALANINE KINASE INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/122921    International Application No.:    PCT/CN2012/072174
Publication Date: 20.09.2012 International Filing Date: 12.03.2012
IPC:
C07D 209/42 (2006.01), A61K 31/404 (2006.01), A61P 35/00 (2006.01)
Applicants: JIANGSU SIMCERE PHARMACEUTICAL R&D CO., LTD. [CN/CN]; No. 699-18, Xuanwu Avenue, Xuanwu District Nanjing, Jiangsu 210042 (CN) (For All Designated States Except US).
TANG, Feng [CN/CN]; (CN) (For US Only).
JIN, Qiu [CN/CN]; (CN) (For US Only).
LI, Wei [CN/CN]; (CN) (For US Only).
ZHU, Tian [CN/CN]; (CN) (For US Only).
HU, Yang [CN/CN]; (CN) (For US Only).
SHAO, Feng [CN/CN]; (CN) (For US Only)
Inventors: TANG, Feng; (CN).
JIN, Qiu; (CN).
LI, Wei; (CN).
ZHU, Tian; (CN).
HU, Yang; (CN).
SHAO, Feng; (CN)
Agent: BEIJING KINSCOM INTELLECTUAL PROPERTY AGENT CO., LTD.; 1701B, Baiyan Building No.238 Beisihuan Zhong Road Haidian, Beijing 100191 (CN)
Priority Data:
201110061774.1 15.03.2011 CN
Title (EN) SALT FORM OF HYDROXYPHENYLALANINE KINASE INHIBITOR
(FR) FORME DE SEL D'UN INHIBITEUR D'HYDROXYPHÉNYLALANINE KINASE
(ZH) 一种酪氨酸激酶抑制剂的盐形式
Abstract: front page image
(EN)The present invention pertains to acidic adduct salts of (Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(1,2-dihydro-5-fluoro-2-oxo-3H-indol-3-ylene)-4,5,6,7-tetrahydro-1H-indol-3-carboxamide, selected from L-malate, hydrochloride, phosphate, L-tartrate, benzene sulfonate, sulfate, methanesulfonate, succinate, citrate, fumarate, p-toluenesulfonate, hydrobromate, L-mandelate, lactate, acetate and maleate, and the use of the above salt compounds for preparing pharmaceuticals.
(FR)La présente invention porte sur des sels d'addition d'acide du (Z)-N-[2-(diéthylamino)éthyl]-2-méthyl-7-(1,2-dihydro-5-fluoro-2-oxo-3H-indol-3-ylène)-4,5,6,7-tétrahydro-1H-indole-3-carboxamide, choisi parmi les sels L-malate, chlorhydrate, phosphate, L-tartrate, benzènesulfonate, sulfate, méthanesulfonate, succinate, citrate, fumarate, p-toluènesulfonate, bromhydrate, L-mandélate, lactate, acétate et maléate, et sur les utilisations des composés sels ci-dessus pour la préparation de produits pharmaceutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)