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1. (WO2012122747) A METHOD FOR PREPARING 2,5-DIMETHYLPHENYLACETIC ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/122747 International Application No.: PCT/CN2011/075370
Publication Date: 20.09.2012 International Filing Date: 07.06.2011
IPC:
C07C 51/10 (2006.01) ,C07C 57/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
51
Preparation of carboxylic acids or their salts, halides, or anhydrides
10
by reaction with carbon monoxide
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
57
Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
30
containing six-membered aromatic rings
Applicants: WANG, Ping[CN/CN]; CN (UsOnly)
FAN, Xiaobin[CN/CN]; CN (UsOnly)
LIN, Xingjun[CN/CN]; CN (UsOnly)
HE, Zhaohui[CN/CN]; CN (UsOnly)
LIANHE CHEMICAL TECHNOLOGY CO., LTD.[CN/CN]; 8 Yongjiao Road, Jiangkou Development Zone, Huangyan Zone Taizhou, Zhejiang 318020, CN (AllExceptUS)
JIANGSU LIANHE CHEMICAL TECHNOLOGY CO., LTD.[CN/CN]; Ecological Industrial District, Xiangshui Yancheng, Jiangsu 224600, CN (AllExceptUS)
Inventors: WANG, Ping; CN
FAN, Xiaobin; CN
LIN, Xingjun; CN
HE, Zhaohui; CN
Agent: TAIZHOU LANTIAN INTELLECTUAL PROPERTY AGENCY; 25-F, New Taizhou Mansion No.18 Aihua Road, Jiaojiang District Taizhou, Zhejiang 318000, CN
Priority Data:
201110060598.X13.03.2011CN
Title (EN) A METHOD FOR PREPARING 2,5-DIMETHYLPHENYLACETIC ACID
(FR) PROCÉDÉ DE PRÉPARATION D'ACIDE 2,5-DIMÉTHYLPHÉNYLACÉTIQUE
(ZH) 一种2,5-二甲基苯乙酸的制备方法
Abstract:
(EN) Provided is a method for preparing 2,5-dimethylphenylacetic acid,wherein p-xylene is mixed with paraformaldehyde and concentrated hydrochloric acid in a solvent of ion liquid to obtain 2,5-dimethyl benzyl chloride by the chloromethylation reaction. Then, 2,5-dimethyl benzyl chloride is introduced into a reactor with an acid binding agent and a solvent, the carbonylation and hydrolysis reaction is conducted in the presence of a catalyst to obtain 2,5-dimethylphenylacetic acid. The present process has new route, less synthesis steps, simple operation, lower cost, increased yield, and is friendly to the environment. Therefore, the method is suitable for industrial production.
(FR) L'invention concerne un procédé de préparation d'acide 2,5-diméthylphénylacétique, selon lequel du p-xylène est mélangé avec du paraformaldéhyde et de l'acide chlorhydrique concentré dans un solvant de liquide ionique pour obtenir du chlorure de 2,5-diméthylbenzyle par la réaction de chlorométhylation. Le chlorure de 2,5-diméthylbenzyle est ensuite introduit dans un réacteur avec un agent de liaison acide et un solvant, la réaction de carbonylation et d'hydrolyse est réalisée en présence d'un catalyseur pour obtenir l'acide 2,5-diméthylphénylacétique. Le présent procédé utilise une nouvelle voie, présente moins d'étapes de synthèse, un fonctionnement simple, un coût réduit, un rendement augmenté et est respectueux de l'environnement. Le procédé est par conséquent approprié pour la production industrielle.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)