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1. (WO2012122444) COMBINATION OF LOCAL AND SYSTEMIC IMMUNOMODULATIVE THERAPIES FOR ENHANCED TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/122444    International Application No.:    PCT/US2012/028412
Publication Date: 13.09.2012 International Filing Date: 09.03.2012
IPC:
C12P 21/08 (2006.01)
Applicants: PROVECTUS PHARMACEUTICALS, INC. [US/US]; 7327 Oak Ridge Highway Knoxville, TN 37931 (US) (For All Designated States Except US).
PFIZER, INC. [US/US]; 235 East 42nd Street New York, New York 10017 (US) (For All Designated States Except US)
Inventors: EAGLE, Craig J.; (US).
DEES, H. Craig; (US).
WACHTER, Eric A.; (US).
SINGER, Jamie; (US)
Agent: MURPHY, Mark J.; Husch Blackwell LLP 120 South Riverside Plaza, Suite 2200 Chicago, IL 60606 (US)
Priority Data:
61/451,395 10.03.2011 US
Title (EN) COMBINATION OF LOCAL AND SYSTEMIC IMMUNOMODULATIVE THERAPIES FOR ENHANCED TREATMENT OF CANCER
(FR) COMBINAISON DE THÉRAPIES IMMUNOMODULATRICES LOCALES ET SYSTÉMIQUES POUR L'AMÉLIORATION DU TRAITEMENT DU CANCER
Abstract: front page image
(EN)A method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic immunomodulatory anticancer agent. A further method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic targeted anticancer agent. The present invention is further directed to pharmaceutical compositions for treatment of cancer. The intralesional chemoablative pharmaceutical composition can comprise an IL chemoablative agent comprising primarily a halogenated xanthene.
(FR)La présente invention concerne une méthode de traitement du cancer comprenant l'administration d'une quantité thérapeutiquement active d'une composition pharmaceutique chimio-ablative intra-lésion, ou d'une variante d'une telle composition, en combinaison avec une quantité thérapeutiquement active d'un agent anticancéreux immunomodulateur systémique. La présente invention concerne en outre une méthode de traitement du cancer comprenant l'administration d'une quantité thérapeutiquement active d'une composition pharmaceutique chimio-ablative intra-lésion, ou d'une variante d'une telle composition, en combinaison avec une quantité thérapeutiquement active d'un agent anticancéreux ciblé systémique. La présente invention concerne également des compositions pharmaceutiques de traitement du cancer. La composition pharmaceutique chimio-ablative intra-lésion peut inclure un agent chimio-ablatif intra-lésion comprenant principalement un xanthène halogéné.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)