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Machine translation
1. (WO2012122372) METHODS OF DETECTING ANTIBODIES SPECIFIC FOR DENATURED HLA ANTIGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/122372    International Application No.:    PCT/US2012/028272
Publication Date: 13.09.2012 International Filing Date: 08.03.2012
IPC:
G01N 33/566 (2006.01)
Applicants: ONE LAMBDA, INC. [US/US]; 21001 Kittridge Street Canoga Park, CA 31303 (US) (For All Designated States Except US).
LEE, Jar-how [US/US]; (US) (For US Only).
PEI, Rui [US/US]; (US) (For US Only).
NONG, Thoa [US/US]; (US) (For US Only)
Inventors: LEE, Jar-how; (US).
PEI, Rui; (US).
NONG, Thoa; (US)
Agent: SINTICH, Sharon, M.; Marshall, Gerstein & Borun LLP 233 S. Wacker Drive 6300 Willis Tower Chicago, IL 60606-6357 (US)
Priority Data:
13/044,430 09.03.2011 US
Title (EN) METHODS OF DETECTING ANTIBODIES SPECIFIC FOR DENATURED HLA ANTIGENTS
(FR) PROCÉDÉS DE DÉTECTION D'ANTICORPS SPÉCIFIQUES POUR DES ANTIGÈNES HLA DÉNATURÉS
Abstract: front page image
(EN)The invention is directed to methods of screening for HLA antibodies comprising detecting antibodies specific for native HLA antigens and denatured HLA antigens. The invention also provides for methods of removing antibodies specific for denatured HLA antigens or antibodies specific for native HLA antigens from a serum sample. In addition, the invention also provides for method of predicting whether a transplant recipient has an increased risk for rejecting the transplanted organ.
(FR)La présente invention concerne des procédés de criblage pour des anticorps anti-HLA comprenant la détection d'anticorps spécifiques pour des antigènes HLA natifs et des antigènes HLA dénaturés. L'invention concerne en outre des procédés de séparation d'anticorps spécifiques pour des antigènes HLA dénaturés ou d'anticorps spécifiques pour des antigènes HLA natifs d'un échantillon de sérum. De plus, l'invention concerne en outre un procédé de prédiction du fait qu'un receveur de transplantation a ou non un risque augmenté de rejeter l'organe transplanté.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)