WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012122370) COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/122370    International Application No.:    PCT/US2012/028263
Publication Date: 13.09.2012 International Filing Date: 08.03.2012
IPC:
G06Q 10/08 (2012.01)
Applicants: EUTROPICS PHARMACEUTICALS, INC. [US/US]; 609 Albany Street Suite 410 Boston, Massachusetts 02118 (US) (For All Designated States Except US).
CARDONE, Michael H. [US/US]; (US) (For US Only).
KOLODZIEJ, Andrew F. [US/US]; (US) (For US Only).
RICHARD, David [US/US]; (US) (For US Only)
Inventors: CARDONE, Michael H.; (US).
KOLODZIEJ, Andrew F.; (US).
RICHARD, David; (US)
Agent: TUSCAN, Michael S.; Cooley LLP 777 6th Street, N.W. Suite 1100 Washington, District of Columbia 20001 (US)
Priority Data:
61/450,369 08.03.2011 US
Title (EN) COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES
(FR) COMPOSITIONS ET MÉTHODES UTILES DANS LE TRAITEMENT DE MALADIES
Abstract: front page image
(EN)The present invention relates to a compositions for and methods of cancer treatment in which compounds of Formula I or Formula II. In some aspects, the treatment of B-cell Lymphoma or other hematopoietic cancers is encompassed. In other aspects, the invention provides methods for treating particular types of hematopoietic cancers, such as B-cell lymphoma, using a combination of one or more compounds of Formula I or Formula II. Combination therapy with, for example, a class of therapeutics known as 26S proteasome inhibitors, for example, Bortezomib, are also included. In another aspect the present invention relates to autoimmune treatment with compounds of Formula I or Formula II. In another aspect, this invention relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have unique in vitrio properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease.
(FR)La présente invention concerne des compositions et des méthodes de traitement du cancer, utilisant les composés de la formule I ou de la formule II. Dans certains aspects, la présente invention englobe le traitement du lymphome B ou d'autres cancers hématopoïétiques. Dans d'autres aspects, l'invention porte sur des méthodes de traitement de types particuliers de cancers hématopoïétiques, tels que le lymphome B, au moyen d'une combinaison d'un ou de plusieurs composés de formule I ou de formule II. L'invention a également trait à une polythérapie utilisant par exemple une catégorie de thérapies connues en tant qu'inhibiteurs du protéasome 26S, par exemple le bortézomib. Dans un autre aspect, la présente invention concerne un traitement de maladies auto-immunes au moyen des composés de formule I ou de formule II. Dans un autre aspect, l'invention concerne des procédés d'identification de composés, par exemple de composés de la catégorie des analogues de BH3, qui possèdent des propriétés in vitro uniques permettant de prédire in vivo l'efficacité contre les lymphomes des lymphocytes B et d'autres cancers, ainsi que des maladies auto-immunes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)