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1. (WO2012122087) EPITOPE FLUCTUATION AND IMMUNOGENICITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/122087    International Application No.:    PCT/US2012/027696
Publication Date: 13.09.2012 International Filing Date: 05.03.2012
IPC:
G06F 19/12 (2011.01)
Applicants: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US/US]; 351 West 10th Street Indianapolis, IN 46202 (US) (For All Designated States Except US).
ORTOLEVA, Peter, J. [US/US]; (US) (For US Only)
Inventors: ORTOLEVA, Peter, J.; (US)
Agent: LARSEN, Joshua, P.; Barnes & Thornburg LLP 11 South Meridian Street Indianapolis, IN 46204 (US)
Priority Data:
61/449,634 05.03.2011 US
Title (EN) EPITOPE FLUCTUATION AND IMMUNOGENICITY
(FR) FLUCTUATION ET IMMUNOGÉNÉCITÉ DE DÉTERMINANT ANTIGÉNIQUE
Abstract: front page image
(EN)Systems and methods for computer-aided vaccine design may comprise performing one or more molecular dynamics simulations of a protein assembly having at least one epitope, determining a fluctuation measurement for the at least one epitope using the one or more molecular dynamics simulations, and predicting the immunogenicity of the protein assembly in response to the fluctuation measurement are disclosed.
(FR)Des systèmes et des procédés de l'invention pour une conception de vaccin assistée par ordinateur peuvent consister à effectuer une ou plusieurs simulations dynamiques moléculaires d'un ensemble de protéines ayant au moins un déterminant antigénique, déterminer une mesure de fluctuation pour le ou les déterminants antigéniques en utilisant la ou les simulations dynamiques moléculaires, et prédire l'immunogénécité de l'ensemble de protéines en réponse à la mesure de fluctuation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)