WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012121058) PHARMACEUTICAL COMPOSITION THAT USES NOVEL PEPTIDE THAT MIMICS TNF RECEPTOR LOOP PEPTIDE CONTAINING CROSS-LINKED STRUCTURE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/121058    International Application No.:    PCT/JP2012/054899
Publication Date: 13.09.2012 International Filing Date: 28.02.2012
IPC:
A61K 38/00 (2006.01), A61P 19/02 (2006.01), A61P 19/08 (2006.01), A61P 19/10 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), A61P 35/04 (2006.01), A61P 43/00 (2006.01), C07K 7/54 (2006.01)
Applicants: Jitsubo Co., Ltd. [JP/JP]; 2-24-16, Naka-cho, Koganei-city Tokyo 1840012 (JP) (For All Designated States Except US).
National University Corporation Tokyo Medical and Dental University [JP/JP]; 5-45, Yushima 1-chome, Bunkyo-ku Tokyo 1138510 (JP) (For All Designated States Except US).
KONO, Yusuke [JP/JP]; (JP) (For US Only).
FUJITA, Shuji [JP/JP]; (JP) (For US Only).
OKUMOTO, Mari [JP/JP]; (JP) (For US Only).
NAKAE, Takashi [JP/JP]; (JP) (For US Only).
SUZUKI, Hideaki [JP/JP]; (JP) (For US Only).
MAEDA, Miki [JP/JP]; (JP) (For US Only).
OHYA, Keiichi [JP/JP]; (JP) (For US Only).
AOKI, Kazuhiro [JP/JP]; (JP) (For US Only)
Inventors: KONO, Yusuke; (JP).
FUJITA, Shuji; (JP).
OKUMOTO, Mari; (JP).
NAKAE, Takashi; (JP).
SUZUKI, Hideaki; (JP).
MAEDA, Miki; (JP).
OHYA, Keiichi; (JP).
AOKI, Kazuhiro; (JP)
Agent: OSAWA, Kenichi; OSAWA IP LAW FIRM, OSK Bldg. 605, 1-11, Sumiyoshi-cho, Shinjuku-ku, Tokyo 1620065 (JP)
Priority Data:
2011-052114 09.03.2011 JP
Title (EN) PHARMACEUTICAL COMPOSITION THAT USES NOVEL PEPTIDE THAT MIMICS TNF RECEPTOR LOOP PEPTIDE CONTAINING CROSS-LINKED STRUCTURE
(FR) COMPOSITION PHARMACEUTIQUE QUI UTILISE UN NOUVEAU PEPTIDE QUI MIME LE PEPTIDE DE BOUCLE DE RÉCEPTEUR DE TNF CONTENANT UNE STRUCTURE RÉTICULÉE
(JA) 新規な架橋構造を含むTNFレセプターループペプチドの模倣ペプチドを用いた医薬組成物
Abstract: front page image
(EN)The purpose of this invention is to provide novel peptide that mimics a TNF receptor loop peptide (WP9QY peptide) having improved properties. More specifically, to provide an osteoporosis therapeutic agent containing a peptide, which has more desirable properties, that mimics the WP9QY peptide. A novel peptide that mimics a TNF receptor loop peptide, which has inhibitory activity against osteoclast differentiation, and which has a cross-linked structure having -NR- in a cross-linked structure, is provided. A pharmaceutical composition containing the peptide and an osteoclast growth inhibitor that uses the peptide is also provided.
(FR)La présente invention concerne un nouveau peptide qui mime un peptide de boucle de récepteur de TNF (peptide WP9QY) ayant des propriétés améliorées. Plus spécifiquement, pour produire un agent thérapeutique contre l'ostéoporose contenant un peptide, qui a des propriétés plus souhaitables, qui mime le peptide WP9QY. Un nouveau peptide qui mime un peptide de boucle de récepteur TNF, qui a une activité inhibitrice contre la différenciation des ostéoclastes, et qui a une structure réticulée ayant -NR- dans une structure réticulée. La présente invention concerne en outre une composition pharmaceutique contenant le peptide et un inhibiteur de croissance d'ostéoclastes qui utilise le peptide.
(JA) 本発明の目的は、改善された特性を持つ新規なTNFレセプターループペプチド(WP9QYペプチド)の模倣ペプチドを提供することである。より具体的には、より望ましい特性を有するWP9QYペプチド模倣体を含む骨粗鬆治療薬を提供することである。 破骨細胞の分化阻害活性をもつ、架橋構造中に-NR-を有する新規な架橋構造をもつTNFレセプターループペプチドの模倣ペプチドが提供された。また、該ペプチドを用いた破骨細胞の増殖阻害剤および該ペプチドを含む医薬組成物が提供された。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)