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1. (WO2012120356) PROCESS FOR THE PREPARATION OF (S)-(+)-OR (R)-(-)-10 HYDROXY DIHYDRODIBENZ[B,F]AZEPINES BY ENANTIOSELECTIVE REDUCTION OF 10, 11-DIHYDRO-10-OXO-5H-DIBENZ[B,F]AZEPINES AND POLYMORPHS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/120356 International Application No.: PCT/IB2012/000410
Publication Date: 13.09.2012 International Filing Date: 06.03.2012
IPC:
C07D 223/22 (2006.01) ,A61K 31/55 (2006.01) ,A61P 25/00 (2006.01)
Applicants: BISWAS,. Sujay[IN/IN]; IN (UsOnly)
DUBEY, Shailendra Kumar[IN/IN]; IN (UsOnly)
BANSAL, Vikas[IN/IN]; IN (UsOnly)
MASAND, Mukesh[IN/IN]; IN (UsOnly)
VIR, Dharam[IN/IN]; IN (UsOnly)
JUBILANT LIFE SCIENCES LIMITED[IN/IN]; Plot 1A, Sector 16A Noida - 201 301 Uttar Pradesh, IN (AllExceptUS)
Inventors: BISWAS,. Sujay; IN
DUBEY, Shailendra Kumar; IN
BANSAL, Vikas; IN
MASAND, Mukesh; IN
VIR, Dharam; IN
Agent: NAIR, Manoj Vasudevan; M/s Lex Orbis (Intellectual Property Practice) 709/710, Tolstoy House 15-17 Tolstoy Marg New Delhi 110 001, IN
Priority Data:
638/DEL/201108.03.2011IN
903/DEL/201130.03.2011IN
Title (EN) PROCESS FOR THE PREPARATION OF (S)-(+)-OR (R)-(-)-10 HYDROXY DIHYDRODIBENZ[B,F]AZEPINES BY ENANTIOSELECTIVE REDUCTION OF 10, 11-DIHYDRO-10-OXO-5H-DIBENZ[B,F]AZEPINES AND POLYMORPHS THEREOF
(FR) PROCÉDÉ DE PRÉPARATION DE (S)-(+)- OU (R)-(-)-10-HYDROXYDIHYDRODIBENZ[B,F]- AZÉPINES PAR RÉDUCTION ÉNANTIOSÉLECTIVE DE 10,11-DIHYDRO-10-OXO-5H- DIBENZ[B,F]AZÉPINES ET DE POLYMORPHES DE CELLES-CI
Abstract: front page image
(EN) The present invention provides a novel process for the preparation of substituted optically pure (S)-(+)- or (R)-(-)-10-hydroxy-dihydrodibenz[b, f]azepines or derivatives thereof, starting from 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepines using boronate esters or their derivatives. The- present invention also provides use of thus prepared (S)-(+)- or (R)-(-)-10-hydroxy-dihydrodibenz[b,f]azepines for the preparation of their ester such as (S)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz[b, f]azepine-5-carboxamide or (R)-(+)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide. The present invention also provides novel solid state crystalline forms J1, J2, J3, J4 and amorphous form of eslicarbazepine and the process for the preparation thereof. Also, the present invention provides novel solid state crystalline form and amorphous form of eslicarbazepine acetate and the process for the preparation thereof. The novel solid state forms of eslicarbazepine are useful for the preparation of derivatives of eslicarbazepine such as eslicarbazepine acetate.
(FR) Cette invention concerne un nouveau procédé permettant de préparer des (S)-(+)- ou (R)-(-)-10-hydroxydihydrodibenz[b,f]azépines substituées, optiquement pures, ou des dérivés de celles-ci, à partir de 10,11-dihydro-10-oxo-5H- dibenz[b,f]azépines à l'aide d'esters de boronates ou de leurs dérivés. La présente invention concerne également l'utilisation des (S)-(+)- ou (R)-(-)-10-hydroxydihydrodibenz[b,f]- azépines ainsi préparées pour la préparation de leur ester, tel que (S)-(-)-10-acétoxy-10,11-dihydro-5H-dibenz[b,f]-azépine-5-carboxamide, ou (R)-(+)-10-acétoxy-10,11-dihydro-5H- dibenz[b,f]azépine-5-carboxamide. Ladite invention concerne également de nouvelles formes cristallines à l'état solide J1, J2, J3, J4 et une forme amorphe de l'eslicarbazépine et leur procédé de préparation. En plus, cette invention concerne une nouvelle forme cristalline et une et forme amorphe à l'état solide d'acétate d'eslicarbazépine et leur procédé de préparation. Les nouvelles formes à l'état solide de l'eslicarbazépine sont utiles pour préparer des dérivés d'eslicarbazépine tels que l'acétate d'eslicarbazépine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)