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1. (WO2012120176) RECOMBINANT PROTEINS HAVING ANTITUMOR EFFECTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/120176 International Application No.: PCT/ES2012/070150
Publication Date: 13.09.2012 International Filing Date: 08.03.2012
IPC:
C12N 9/22 (2006.01) ,A61K 38/46 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
22
Ribonucleases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
Applicants: VILANOVA BRUGUES, María[ES/ES]; ES (UsOnly)
BENITO MUNDET, Antoni[ES/ES]; ES (UsOnly)
RIBÓ PANOSA, Marc[ES/ES]; ES (UsOnly)
CASTRO GALLEGOS, Jessica[ES/ES]; ES (UsOnly)
TUBERT JUHE, Pere[ES/ES]; ES (UsOnly)
VERT COMPANY, Anna[ES/ES]; ES (UsOnly)
UNIVERSITAT DE GIRONA[ES/ES]; Plaça Sant Domenech, 3 Edifici les Àligues E-17071 Girona, ES (AllExceptUS)
Inventors: VILANOVA BRUGUES, María; ES
BENITO MUNDET, Antoni; ES
RIBÓ PANOSA, Marc; ES
CASTRO GALLEGOS, Jessica; ES
TUBERT JUHE, Pere; ES
VERT COMPANY, Anna; ES
Agent: ZEA CHECA, Bernabé; Pl. Catalunya, 1 E-08002 Barcelona, ES
Priority Data:
P20113032410.03.2011ES
Title (EN) RECOMBINANT PROTEINS HAVING ANTITUMOR EFFECTS
(FR) PROTÉINES RECOMBINANTES À EFFET ANTITUMORAL
(ES) PROTEÍNAS RECOMBINANTES CON EFECTO ANTITUMORAL
Abstract:
(EN) The invention relates to the provision of a recombinant protein comprising ribonuclease activity, which includes a sequence derived from human pancreatic ribonuclease (RNasa-PH) having the sequence SEC ID NO: 37, which is fused by the N-terminal end thereof to a conventional nuclear localization sequence. The invention further relates to a recombinant DNA molecule that codes for said protein, to a vector that includes said DNA molecule and to a cell that includes said vector. The invention additionally relates to a method for producing the recombinant protein and to the use of same as an antitumor agent.
(FR) La présente invention concerne une protéine recombinante à activité ribonucléase qui comporte une séquence dérivée de la ribonucléase pancréatique humaine (RNasa-PH) de la séquence SEC ID NO: 37 fusionnée par son extrémité N-terminal à une séquence de localisation nucléaire classique, ainsi qu'une molécule d'ADN recombinant qui code pour cette protéine, un vecteur qui comprend ladite molécule d'ADN, et une cellule comportant ledit vecteur. En outre, cette invention a trait à un procédé d'obtention de la protéine recombinante et son utilisation en tant qu'agent antitumoral.
(ES) La presente invención proporciona una proteína recombinante con actividad ribonucleasa que comprende una secuencia derivada de la ribonucleasa pancreática humana (RNasa-PH) de secuencia SEC ID NO: 37 fusionada a través de su extremo N-terminal a una secuencia de localización nuclear convencional, así como una molécula de ADN recombinante que codifica para esta proteína, un vector que comprende dicha molécula de ADN y una célula que comprende dicho vector. Adicionalmente la presente invención está referida a un procedimiento para la obtención de la proteína recombinante y el uso de la misma como agente antitumoral.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)