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Machine translation
1. (WO2012119883) 1,4 THIAZEPINES/SULFONES AS BACE1 AND/OR BACE2 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/119883 International Application No.: PCT/EP2012/053298
Publication Date: 13.09.2012 International Filing Date: 28.02.2012
IPC:
C07D 417/12 (2006.01) ,C07D 513/04 (2006.01) ,A61K 31/554 (2006.01) ,A61P 25/16 (2006.01) ,A61P 3/10 (2006.01)
Applicants: HILPERT, Hans[CH/CH]; CH (UsOnly)
ROGERS-EVANS, Mark[GB/CH]; CH (UsOnly)
ROMBACH, Didier[FR/FR]; FR (UsOnly)
F. HOFFMANN-LA ROCHE AG[CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
Inventors: HILPERT, Hans; CH
ROGERS-EVANS, Mark; CH
ROMBACH, Didier; FR
Agent: MUELLER-AFRAZ, Simona; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data:
11156976.004.03.2011EP
Title (EN) 1,4 THIAZEPINES/SULFONES AS BACE1 AND/OR BACE2 INHIBITORS
(FR) 1,4 THIAZEPINES/SULFONES UTILISÉS COMME INHIBITEURS DE BACE1 ET/OU BACE2 INHIBITORS
Abstract: front page image
(EN) The present invention relates to 1,4 Thiazepines/Sulfones of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
(FR) L'invention concerne des 1,4 thiazepines/sulfones représentés par la formule (I) présentant une activité inhibitrice de BACE1 et/ou BACE2, leur préparation, des compositions pharmaceutiques les comprenant et leur utilisation en tant que substances thérapeutiquement actives. Les composés actifs de l'invention sont utilisés dans le traitement thérapeutique et/ou prophylactique, par exemple de la maladie d'Alzheimer et du diabète de type 2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)