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1. (WO2012119212) IMIDAZOLIDINE AND THIAZOLIDINE MOLECULES WITH ANTI-T. CRUZI ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/119212 International Application No.: PCT/BR2012/000060
Publication Date: 13.09.2012 International Filing Date: 08.03.2012
IPC:
A61K 31/475 (2006.01) ,A61K 31/427 (2006.01) ,A61K 31/426 (2006.01) ,A61K 31/473 (2006.01) ,A61K 31/4166 (2006.01) ,A61K 31/519 (2006.01) ,C07D 277/34 (2006.01) ,C07D 417/06 (2006.01) ,C07D 401/06 (2006.01) ,C07D 233/96 (2006.01) ,A61P 33/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
475
having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
427
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
473
ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4166
having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
34
Oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
96
having three double bonds between ring members or between ring members and non-ring members
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
02
Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Applicants: GALDINO, Suely Lins[BR/BR]; BR (UsOnly)
MOREIRA, Thiago Luiz De Barros[BR/BR]; BR (UsOnly)
DE CARVALHO, Tecia Maria Ulisses[BR/BR]; BR (UsOnly)
DE SOUZA, Wanderley[BR/BR]; BR (UsOnly)
HENRIQUES, Cristina[BR/BR]; BR (UsOnly)
PITTA, Ivan Da Rocha[BR/BR]; BR (UsOnly)
DE LIMA, Maria Do Carmo Alves[BR/BR]; BR (UsOnly)
HERNANDES, Marcelo Zaldini[BR/BR]; BR (UsOnly)
PEREIRA, Valéria Rêgo Alves[BR/BR]; BR (UsOnly)
UNIVERSIDADE FEDERAL DE PERNAMBUCO[BR/BR]; Av. Professor Moraes Rego, 1235 CEP: 50670-901 - Cidade Universitária - Recife Pernambuco - Brasil, BR (AllExceptUS)
Inventors: GALDINO, Suely Lins; BR
MOREIRA, Thiago Luiz De Barros; BR
DE CARVALHO, Tecia Maria Ulisses; BR
DE SOUZA, Wanderley; BR
HENRIQUES, Cristina; BR
PITTA, Ivan Da Rocha; BR
DE LIMA, Maria Do Carmo Alves; BR
HERNANDES, Marcelo Zaldini; BR
PEREIRA, Valéria Rêgo Alves; BR
Priority Data:
PI 1101273-010.03.2011BR
Title (EN) IMIDAZOLIDINE AND THIAZOLIDINE MOLECULES WITH ANTI-T. CRUZI ACTIVITY
(FR) MOLÉCULES IMIDAZOLIDINIQUES ET THIAZOLIDINIQUES À ACTIVITÉ ANTI-T.CRUZI
(PT) MOLÉCULAS IMIDAZOLIDÍNICAS E TIAZOLIDÍNICAS COM ATIVIDADE ANTI-T.CRUZI
Abstract:
(EN) The present invention relates to the synthesis and structural identification of new thiazolidine and imidazolidine compounds with trypanocidal activity, and to the therapeutic use thereof as drugs against Chagas disease.
(FR) La présente invention concerne la synthèse et l'identification structurale de nouveaux composés thiazolidiniques et imidazolidiniques à activité trypanocide, ainsi que leur utilisation thérapeutique comme médicaments contre la maladie de Chagas.
(PT) A presente invenção refere-se à síntese e identificação estrutural de novos compostos tiazolidínicos e imidaziolidínicos com atividade TRIPANOCIDA e seu uso terapêutico como drogas anti-chagásicas.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Portuguese (PT)
Filing Language: Portuguese (PT)