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Pub. No.:    WO/2012/119051    International Application No.:    PCT/US2012/027431
Publication Date: 07.09.2012 International Filing Date: 02.03.2012
C12Q 1/68 (2006.01), C12N 15/113 (2010.01), A61K 48/00 (2006.01), A61K 31/7105 (2006.01), C12N 15/63 (2006.01)
Applicants: GROOVE BIOPHARMA CORPORATION [US/US]; 1616 Eastlake Avenue East Suite 200 Seattle, WA 98102 (US) (For All Designated States Except US).
MCELLIGOTT, David L. [US/US]; (US) (For US Only)
Inventors: MCELLIGOTT, David L.; (US)
Agent: MCDONALD, Michael J.; Cooley LLP 777 6th Street, NW Suite 1100 Washington, District of Columbia 20001 (US)
Priority Data:
61/448,618 02.03.2011 US
Abstract: front page image
(EN)This invention relates generally to oligomers useful for modulating expression and/or activity of RNAs or genes. More particularly, the invention relates to single stranded, double stranded, partially double stranded and hairpin structured chemically modified oligomers that have a broad biodistribution profile for inhibiting RNA expression in a plurality of cells, tissues, or organs, and to methods of making and using the modified oligomers.
(FR)La présente invention concerne en général des oligomères utiles pour la modulation de l'expression et/ou de l'activité d'ARN ou de gènes. Plus particulièrement, elle concerne des oligomères chimiquement modifiés à structure en épingle à cheveux, à simple brin, à double brin et à double brin partiel qui présentent un profil de large biodistribution permettant d'inhiber l'expression d'ARN dans une pluralité de cellules, de tissus ou d'organes. Elle concerne également des procédés de fabrication et d'utilisation des oligomères modifiés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)