WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012118911) OLIGONUCLEOTIDE MODULATORS OF THE TOLL-LIKE RECEPTOR PATHWAY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/118911    International Application No.:    PCT/US2012/027174
Publication Date: 07.09.2012 International Filing Date: 01.03.2012
IPC:
C12N 15/113 (2010.01)
Applicants: QUARK PHARMACEUTICALS, INC. [US/US]; 6501 Dumbarton Circle Fremont, California 94555 (US) (For All Designated States Except US).
FEINSTEIN, Elena [IL/IL]; (IL) (For US Only).
ADAMSKY, Svetlana [IL/IL]; (IL) (For US Only).
AVKIN-NACHUM, Sharon [IL/IL]; (IL) (For US Only).
KALINSKI, Hagar [IL/IL]; (IL) (For US Only).
METT, Igor [IL/IL]; (IL) (For US Only)
Inventors: FEINSTEIN, Elena; (IL).
ADAMSKY, Svetlana; (IL).
AVKIN-NACHUM, Sharon; (IL).
KALINSKI, Hagar; (IL).
METT, Igor; (IL)
Priority Data:
61/448,707 03.03.2011 US
Title (EN) OLIGONUCLEOTIDE MODULATORS OF THE TOLL-LIKE RECEPTOR PATHWAY
(FR) MODULATEURS DES OLIGONUCLÉOTIDES DE LA VOIE DE SIGNALISATION ACTIVÉE PAR LES RÉCEPTEURS DE TYPE TOLL
Abstract: front page image
(EN)Disclosed herein are double stranded nucleic acid molecules and pharmaceutical compositions comprising same useful in the treatment of, inter alia, acute and chronic inflammation, neuropathic pain, primary graft dysfunction (PGD) after lung transplantation in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA compounds, which down regulate or inhibit expression of a Toll like receptor genes.
(FR)La présente invention se rapporte à des molécules d'acide nucléique double brin et à des compositions pharmaceutiques les contenant. Les molécules d'acide nucléique double brin et les compositions pharmaceutiques selon l'invention sont utiles dans le traitement, entre autres, d'inflammations aiguës et chroniques, de douleurs neuropathiques, d'un dysfonctionnement du greffon primaire (PGD, Primary Graft Dysfunction) après une transplantation pulmonaire chez un sujet en ayant besoin. Les composés sont de préférence des composés ARN à double brin modifiés et synthétisés chimiquement, qui régulent à la baisse ou inhibent l'expression des gènes d'un récepteur de type Toll.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)