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1. (WO2012118850) SERINE/THREONINE KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/118850 International Application No.: PCT/US2012/027009
Publication Date: 07.09.2012 International Filing Date: 28.02.2012
IPC:
C07D 471/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants: BLAKE, James F.[US/US]; US (UsOnly)
CHEN, Huifen[US/US]; US (UsOnly)
CHICARELLI, Mark Joseph[US/US]; US (UsOnly)
DEMEESE, Jason[US/US]; US (UsOnly)
GARREY, Rustam[US/US]; US (UsOnly)
GAUDINO, John J.[US/US]; US (UsOnly)
KAUS, Robert J.[US/US]; US (UsOnly)
KOLAKOWSKI, Gabrielle R.[US/US]; US (UsOnly)
MARLOW, Allison L.[US/US]; US (UsOnly)
MOHR, Peter J.[US/US]; US (UsOnly)
REN, Li[CA/US]; US (UsOnly)
SCHWARZ, Jacob[US/US]; US (UsOnly)
SIEDEM, Christopher S.[US/US]; US (UsOnly)
THOMAS, Allen A.[US/US]; US (UsOnly)
WALLACE, Eli[US/US]; US (UsOnly)
WENGLOWSKY, Steven Mark[US/US]; US (UsOnly)
ARRAY BIOPHARMA INC.[US/US]; 3200 Walnut Street Boulder, Colorado 80301, US (AllExceptUS)
GENENTECH, INC.[US/US]; 1 DNA Way South San Francisco, California 94080-4990, US (AllExceptUS)
Inventors: BLAKE, James F.; US
CHEN, Huifen; US
CHICARELLI, Mark Joseph; US
DEMEESE, Jason; US
GARREY, Rustam; US
GAUDINO, John J.; US
KAUS, Robert J.; US
KOLAKOWSKI, Gabrielle R.; US
MARLOW, Allison L.; US
MOHR, Peter J.; US
REN, Li; US
SCHWARZ, Jacob; US
SIEDEM, Christopher S.; US
THOMAS, Allen A.; US
WALLACE, Eli; US
WENGLOWSKY, Steven Mark; US
Agent: HARRIS, Robert J.; Viksnins Harris & Padys PLLP P.O. Box 111098 Saint Paul, Minnesota 55111-1098, US
Priority Data:
61/447,58728.02.2011US
Title (EN) SERINE/THREONINE KINASE INHIBITORS
(FR) INHIBITEURS DE SÉRINE/THRÉONINE KINASE
Abstract:
(EN) Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
(FR) L'invention concerne des composés de la formule I où Z, Z1 Z2 Z3, R3a, R3b et Rb sont tels que définis par les présentes, et sont des inhibiteurs de kinase ERK. L'invention concerne également des compositions et des méthodes de traitement de troubles d'hyperprolifération.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)