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1. (WO2012118172) DRUG FOR IMPROVING CENTRAL FUNCTIONS DURING PAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/118172    International Application No.:    PCT/JP2012/055328
Publication Date: 07.09.2012 International Filing Date: 02.03.2012
Chapter 2 Demand Filed:    04.01.2013    
IPC:
A61K 45/06 (2006.01), A61K 31/165 (2006.01), A61K 31/435 (2006.01), A61K 31/4436 (2006.01), A61K 31/485 (2006.01), A61K 31/495 (2006.01), A61P 25/00 (2006.01), A61P 25/04 (2006.01), A61P 43/00 (2006.01)
Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY [JP/JP]; 2-39-1, Kurokami, Kumamoto-shi, Kumamoto 8608555 (JP) (For All Designated States Except US).
TAKAHAMA Kazuo [JP/JP]; (JP) (For US Only).
KAWAURA Kazuaki [JP/JP]; (JP) (For US Only).
HONDA Soukichi [JP/JP]; (JP) (For US Only).
SHIRASAKI Tetsuya [JP/JP]; (JP) (For US Only).
SOEDA Fumio [JP/JP]; (JP) (For US Only).
URASHIMA Yuri [JP/JP]; (JP) (For US Only)
Inventors: TAKAHAMA Kazuo; (JP).
KAWAURA Kazuaki; (JP).
HONDA Soukichi; (JP).
SHIRASAKI Tetsuya; (JP).
SOEDA Fumio; (JP).
URASHIMA Yuri; (JP)
Agent: MATSUO Kenichiro; 7th Floor, Shinkumi Akasaka Bldg., 10-17, Akasaka 1-chome, Chuo-ku, Fukuoka-shi, Fukuoka 8100042 (JP)
Priority Data:
2011-047004 03.03.2011 JP
Title (EN) DRUG FOR IMPROVING CENTRAL FUNCTIONS DURING PAIN
(FR) MÉDICAMENT POUR AMÉLIORATION DES FONCTIONS CENTRALES PENDANT LA DOULEUR
(JA) 疼痛における中枢機能改善薬
Abstract: front page image
(EN)Provided is a drug for improving central functions during pain having as active ingredients a narcotic analgesic and a compound having an inhibitory effect on GIRK channel activation current (a GIRK channel inhibiting compound). This drug for improving central functions during pain comprises a GIRK channel inhibiting compound such as tipepidine and a narcotic analgesic such as morphine, wherein the dosis of the GIRK channel inhibiting compound does not by itself exhibit an analgesic effect on pain, nor does the dosis of the narcotic analgesic by itself exhibit an analgesic effect on pain, but this drug improves central functions during pain with few side effects when the doses of the two components are combined.
(FR)L'invention concerne un médicament qui permet d'améliorer les fonctions centrales, pendant la douleur, et qui présente, en tant que principes actifs, un analgésique narcotique et un composé présentant un effet inhibiteur sur le courant d'activation du canal GIRK (un composé inhibiteur du canal GIRK). Ce médicament pour l'amélioration des fonctions centrales pendant la douleur comporte un composé inhibiteur du canal GIRK, tel que la tipépidine, et un analgésique narcotique, tel que la morphine, la dose du composé inhibiteur du canal GIRK ne présentant pas, par elle-même, d'effet analgésique sur la douleur, tout comme la dose de l'analgésique narcotique, par elle-même, ne présente pas d'effet analgésique sur la douleur, mais ce médicament améliore les fonctions centrales pendant la douleur en présentant peu d'effets secondaires lorsque les doses des deux composants sont combinées.
(JA) GIRKチャンネル活性化電流抑制作用を有する化合物(GIRKチャンネル抑制化合物)と麻薬性鎮痛薬とを有効成分として含有する疼痛における中枢機能改善薬を提供すること。 この発明に係る疼痛における中枢機能改善薬は、チぺピジンなどのGIRKチャンネル抑制化合物とモルヒネなどの麻薬性鎮痛薬とからなり、GIRKチャンネル抑制化合物がそれ単独では疼痛に対する鎮痛作用効果を発現しない用量であり、また麻薬性鎮痛薬もそれ単独では疼痛に対する鎮痛作用効果を発現しない用量であるが、これらの用量を合わせると疼痛における中枢機能を改善することができ、かつ、副作用が少ない薬剤である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)