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Pub. No.:    WO/2012/116663    International Application No.:    PCT/CN2012/073509
Publication Date: 07.09.2012 International Filing Date: 05.04.2012
Chapter 2 Demand Filed:    17.07.2012    
C07K 14/435 (2006.01), A61K 38/17 (2006.01), A61P 7/02 (2006.01)
Applicants: GUANGDONG MEDICAL COLLEGE [CN/CN]; No. 2, Wenming Donglu, Xiashan District Zhanjiang, Guangdong 524023 (CN) (For All Designated States Except US).
PENG, Lifei [CN/CN]; (CN) (For US Only).
GAN, Weiqiong [CN/CN]; (CN) (For US Only).
SHAO, Zheng [CN/CN]; (CN) (For US Only).
HE, Qingfeng [CN/CN]; (CN) (For US Only).
DENG, Li [CN/CN]; (CN) (For US Only).
HU, Jingjing [CN/CN]; (CN) (For US Only).
LIAO, Shuli [CN/CN]; (CN) (For US Only).
PENG, Jida [CN/CN]; (CN) (For US Only)
Inventors: PENG, Lifei; (CN).
GAN, Weiqiong; (CN).
SHAO, Zheng; (CN).
HE, Qingfeng; (CN).
DENG, Li; (CN).
HU, Jingjing; (CN).
LIAO, Shuli; (CN).
PENG, Jida; (CN)
Agent: SEMENY INTELLECTUAL PROPERTY FIRM; Room 207 Building 16, 7 Qu, Hepingli, Dongcheng District Beijing 100013 (CN)
Priority Data:
201110097205.2 15.04.2011 CN
(ZH) 一类抗凝血多肽及其应用
Abstract: front page image
(EN)Disclosed is an anticoagulant polypeptide and applications thereof. The anticoagulant polypeptide comprises a polypeptide formed by an amino acid sequence as represented in Seq. ID No. 1; or comprises a derived polypeptide that selectively inhibits coagulation factor Xla and is formed by an amino acid sequence, as represented in Seq. ID No. 1, that has undergone one or multiple amino acid residue substitutions, deletions, or insertions. The anticoagulant polypeptide is a selective inhibitor for coagulation factor Xla, has anticoagulant activity and small side-effect, and can be used in preparing medicines for the prevention and treatment of thrombotic diseases.
(FR)L'invention concerne un polypeptide anticoagulant et des applications de celui-ci. Le polypeptide anticoagulant comprend un polypeptide constitué d'une séquence d'acides aminés représentée dans Seq. ID No. 1; ou comprend un polypeptide dérivé, qui inhibe sélectivement le facteur de coagulation XIa et est constitué d'une séquence d'acides aminés représentée dans Seq. ID No. 1, ladite séquence présentant une ou de multiples substitutions, délétions ou insertions de résidus d'acides aminés. Ce polypeptide anticoagulant constitue un inhibiteur sélectif du facteur de coagulation XIa, possède une activité anticoagulante et peu d'effets secondaires et peut être utilisé dans la préparation de médicaments destinés à prévenir et à traiter des maladies thrombotiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)