WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Options
Query Language
Stem
Sort by:
List Length
Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2012116453) MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/116453 International Application No.: PCT/CA2012/050131
Publication Date: 07.09.2012 International Filing Date: 02.03.2012
IPC:
C07K 19/00 (2006.01) ,C07K 14/47 (2006.01) ,C07K 14/485 (2006.01) ,C07K 14/605 (2006.01) ,C07K 14/76 (2006.01) ,C07K 16/00 (2006.01) ,C07K 16/18 (2006.01) ,C07K 16/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
485
Epidermal growth factor (EGF) (urogastrone)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
605
Glucagons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
76
Albumins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
Applicants: DIXIT, Surjit Bhimarao[IN/CA]; CA (UsOnly)
D'ANGELO, Igor Edmondo Paolo[CA/CA]; CA (UsOnly)
POON, David Kai Yuen[CA/CA]; CA (UsOnly)
ZYMEWORKS INC.[CA/CA]; 540 - 1385 West 8th Avenue Vancouver, British Columbia V6H 3V9, CA (AllExceptUS)
Inventors: DIXIT, Surjit Bhimarao; CA
D'ANGELO, Igor Edmondo Paolo; CA
POON, David Kai Yuen; CA
Agent: SALISBURY, Clare; Gowling Lafleur Henderson LLP 550 Burrard Street Suite 2300, Bentall 5 Vancouver, British Columbia V6C 2B5, CA
Priority Data:
61/449,01603.03.2011US
Title (EN) MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS
(FR) CONCEPTION ET CONSTRUCTIONS D'ÉCHAFAUDAGE HÉTÉROMULTIMÈRE MULTIVALENT
Abstract:
(EN) Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at least one cargo polypeptide, attached to a transporter polypeptide, such that said monomeric proteins associate to form the heteromultimer. These therapeutically novel molecules comprise monomers that function as scaffolds for the conjugation or fusion of therapeutic molecular entities resulting in the creation of bispecific or multivalent molecular species.
(FR) La présente invention concerne des protéines hétéromères multifonctionnelles. Dans des modes de réalisation spécifiques, l'invention concerne un hétéromultimère qui comprend : au moins deux protéines monomériques, chaque protéine monomérique comprenant au moins un polypeptide cargo fixé à un polypeptide transporteur, de telle sorte que lesdites protéines monomériques s'associent pour former l'hétéromultimère. Ces molécules thérapeutiquement nouvelles comprennent des monomères qui fonctionnent en tant qu'échafaudages pour la conjugaison ou la fusion d'entités moléculaires thérapeutiques, conduisant à la création d'espèces moléculaires bispécifiques ou multivalentes.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)