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1. (WO2012116439) BIOMATERIAL, METHOD FOR MAKING THE BIOMATERIAL AND USES OF THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/116439    International Application No.:    PCT/CA2012/000192
Publication Date: 07.09.2012 International Filing Date: 28.02.2012
IPC:
C08L 89/00 (2006.01), A61K 38/17 (2006.01), A61L 27/22 (2006.01), A61L 27/48 (2006.01), A61L 27/52 (2006.01), A61P 19/08 (2006.01), C08J 3/075 (2006.01), C09D 189/00 (2006.01), C12P 21/06 (2006.01), C07K 14/435 (2006.01), C07K 17/04 (2006.01)
Applicants: MCGILL UNIVERSITY [CA/CA]; Office of Sponsored Research James Administration Building 845 Sherbrooke Street West, 2nd Floor Montreal, Québec H3A 2T5 (CA) (For All Designated States Except US).
INNOVHUB-STAZIONI SPERIMENTALI PER L'INDUSTRIA [IT/IT]; Via Camperia, 1 I-20123 Milan (IT) (For All Designated States Except US).
NAZHAT, Showan, N. [GB/CA]; (CA) (For US Only).
MARELLI, Benedetto [IT/CA]; (CA) (For US Only).
BARRALET, Jake, E. [GB/CA]; (CA) (For US Only).
FREDDI, Giuliano [IT/IT]; (IT) (For US Only).
ALESSANDRINO, Antonio [IT/IT]; (IT) (For US Only)
Inventors: NAZHAT, Showan, N.; (CA).
MARELLI, Benedetto; (CA).
BARRALET, Jake, E.; (CA).
FREDDI, Giuliano; (IT).
ALESSANDRINO, Antonio; (IT)
Agent: YAMAC, Tuba; Gowling Lafleur Henderson LLP 1 Place Ville Marie, 37th Floor Montréal, Québec H3S 3P4 (CA)
Priority Data:
61/447,375 28.02.2011 US
Title (EN) BIOMATERIAL, METHOD FOR MAKING THE BIOMATERIAL AND USES OF THE SAME
(FR) BIOMATÉRIAU, PROCÉDÉ DE FABRICATION DU BIOMATÉRIAU ET SES UTILISATIONS
Abstract: front page image
(EN)A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction Cs, and a precipitated fraction Cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor. Use of the biomaterial for constructing, regenerating, repairing, replacing or augmenting soft or hard tissue; as an in vitro or in vivo construct; as a coating material; or as a cell, molecule or particle delivery medium. Use of the isolated and extracted polypeptide fraction Cs for promoting osteoinduction, osteoconduction or osteogenesis. Use of the isolated and extracted polypeptide fraction Cp for enhancing a mechanical compressive modulus of a material into which it is incorporated.
(FR)L'invention concerne un procédé de fabrication d'un biomatériau, comprenant l'apport d'au moins une fraction polypeptidique isolée et extraite de façon chymotryptique à partir de la fibroïne, et l'addition de ladite fraction polypeptidique extraite à un précurseur d'hydrogel avant la gélification, ladite fraction polypeptidique isolée et extraite étant choisie parmi une fraction soluble Cs et une fraction précipitée Cp. L'invention concerne un biomatériau comprenant au moins une des fractions polypeptidiques isolées et extraites, incorporée dans un hydrogel ou un précurseur d'hydrogel. L'invention concerne également l'utilisation du biomatériau pour la construction, la régénération, la réparation, le remplacement ou l'augmentation d'un tissu mou ou dur ; en tant que construction in vitro ou in vivo ; en tant que matière de revêtement ; ou en tant que milieu d'administration de cellule, de molécule ou de particule. L'invention concerne également l'utilisation de la fraction polypeptidique Cs isolée et extraite pour la promotion de l'ostéoinduction, de l'ostéoconduction ou de l'ostéogenèse. L'invention concerne également l'utilisation de la fraction polypeptidique Cp isolée et extraite pour l'amélioration d'un module d'élasticité en compression mécanique d'une matière dans laquelle elle est incorporée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)