WO2012116289 MICROBIAL SIGNATURES AS INDICATORS OF RADIATION EXPOSURE

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Publication Number WO/2012/116289

Publication Date 30.08.2012

International Application No. PCT/US2012/026541

International Filing Date 24.02.2012

IPC

CPC

Applicants

TRICORDER DIAGNOSTICS, LLC [US]/[US] (AllExceptUS)
BAKER, John, Edward [GB]/[US] (UsOnly)

Inventors

BAKER, John, Edward

Agents

JARRELL, Brenda, Herschbach

Priority Data

61/446,696	25.02.2011	US
61/451,930	11.03.2011	US
61/479,786	27.04.2011	US
61/491,452	31.05.2011	US

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) MICROBIAL SIGNATURES AS INDICATORS OF RADIATION EXPOSURE

(FR) SIGNATURES MICROBIENNES COMME INDICATEURS D'EXPOSITION AUX RADIATIONS

Abstract

(EN) The present disclosure defines a method for identifying and characterizing radiation exposure after, for example, a nuclear event such as detonation of a nuclear weapon or a nuclear meltdown of a nuclear power plant, using changes in microbiomes. The present disclosure demonstrates that microbiomes are reproducibly and detectably altered by exposure to radiation. As described herein, microbial signatures can be used to characterize components of microbiomes that are altered by exposure to radiation.

(FR) La présente invention définit une méthode d'identification et de caractérisation d'une exposition aux radiations après, par exemple, un incident nucléaire tel que la détonation d'une arme nucléaire ou la fusion du cœur d'une centrale nucléaire, à l'aide des modifications de microbiomes. La présente invention prouve que les microbiomes sont modifiés par l'exposition aux radiations de façon reproductible et détectable. Selon l'invention, les signatures microbiennes peuvent être utilisées pour caractériser les composants de microbiomes qui sont modifiés par une exposition aux radiations.

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02	involving viable microorganisms

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68	involving nucleic acids

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02	involving viable microorganisms

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68	involving nucleic acids

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02	involving viable microorganisms
025	for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics

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1. WO2012116289 - MICROBIAL SIGNATURES AS INDICATORS OF RADIATION EXPOSURE

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800	Detection or diagnosis of diseases
40	Disorders due to exposure to physical agents, e.g. heat disorders, motion sickness, radiation injuries, altitude sickness, decompression illness

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68	involving proteins, peptides or amino acids
6893	related to diseases not provided for elsewhere

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68	involving proteins, peptides or amino acids
6893	related to diseases not provided for elsewhere