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1. (WO2012116196) SUBSTITUTED LACTOSYL COMPOUNDS AND USE THEREOF FOR CELLULAR IMAGING AND THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/116196    International Application No.:    PCT/US2012/026344
Publication Date: 30.08.2012 International Filing Date: 23.02.2012
IPC:
C07H 3/04 (2006.01), C07H 7/02 (2006.01), C07H 17/02 (2006.01), A61K 31/7016 (2006.01), A61K 31/7028 (2006.01), A61K 31/7056 (2006.01), A61P 35/00 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th St. Austin, TX 78701 (US) (For All Designated States Except US).
TURKMAN, Nashaat [--/US]; (US) (For US Only).
PAL, Ashutosh [IN/IN]; (IN) (For US Only).
TONG, William, B. [US/US]; (US) (For US Only).
GELOVANI, Juri, G. [US/US]; (US) (For US Only).
ALAUDDIN, Mian, M. [US/US]; (US) (For US Only)
Inventors: TURKMAN, Nashaat; (US).
PAL, Ashutosh; (IN).
TONG, William, B.; (US).
GELOVANI, Juri, G.; (US).
ALAUDDIN, Mian, M.; (US)
Agent: BYRD, Marshall, P.; Parker Highlander, PLLC 1120 S. Capital of Texas Highway Building One, Suite 200 Austin, TX 78746 (US)
Priority Data:
61/446,183 24.02.2011 US
Title (EN) SUBSTITUTED LACTOSYL COMPOUNDS AND USE THEREOF FOR CELLULAR IMAGING AND THERAPY
(FR) COMPOSÉS LACTOSYLIQUES SUBSTITUÉS ET LEUR UTILISATION POUR L'IMAGERIE ET LA THÉRAPIE CELLULAIRES
Abstract: front page image
(EN)The invention provides methods for producing compounds comprising a substitution at the 1'-position of a lactosyl ring. Also provided are compounds having a radionuclide, such as 18F substituted at the 1'-position of a lactosyl ring. Compounds according to the invention may be used as therapeutics or imaging agents, such as PET imaging agents. Methods for therapeutic and diagnostic use of substituted lactosyl compounds are also provided.
(FR)L'invention porte sur des procédés qui permettent d'obtenir des composés comportant une substitution au niveau de la position 1' d'un noyau lactosyle. L'invention porte également sur des composés ayant un radionucléide, tels qu'un composé substitué par 18F au niveau de la position 1' d'un noyau lactosyle. Les composés selon l'invention peuvent être utilisés en tant qu'agents thérapeutiques ou d'imagerie, tels que des agents d'imagerie par TEP. L'invention porte également sur des procédés pour l'utilisation thérapeutique et diagnostique de composés lactosyliques substitués.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)