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1. (WO2012116176) ASYMMETRIC UREAS AND MEDICAL USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/116176    International Application No.:    PCT/US2012/026315
Publication Date: 30.08.2012 International Filing Date: 23.02.2012
IPC:
C07C 275/06 (2006.01), C07C 275/26 (2006.01), C07D 213/00 (2006.01)
Applicants: HELSINN HEALTHCARE SA [CH/CH]; Via Pian Scairolo 9 CH-6912 Lugano/Pazzallo (CH) (For All Designated States Except US).
GARCIA RUBIO, Silvina [UY/US]; (US) (For US Only).
PIETRA, Claudio [IT/IT]; (IT) (For US Only).
GIULIANO, Claudio [IT/IT]; (IT) (For US Only).
LI, Zhigang [CN/CN]; (CN) (For US Only)
Inventors: GARCIA RUBIO, Silvina; (US).
PIETRA, Claudio; (IT).
GIULIANO, Claudio; (IT).
LI, Zhigang; (CN)
Agent: SULLIVAN, Clark, G.; Arnall Golden Gregory LLP 171 17th Street NW Suite 2100 Atlanta, GA 30363 (US)
Priority Data:
61/466,070 22.03.2011 US
PCT/CN2011/00298 25.02.2011 CN
Title (EN) ASYMMETRIC UREAS AND MEDICAL USES THEREOF
(FR) URÉES ASYMÉTRIQUES ET UTILISATIONS MÉDICALES DE CELLES-CI
Abstract: front page image
(EN)Compounds of Formula (I), known as asymmetric ureas, are useful for preventing and/or treating diseases that are pathophysiologic ally related to the ghrelin receptor in a subject. Method of treating a disease that is mediated by the ghrelin receptor, comprising administering to said subject a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or adduct thereof. Pharmaceutical compositions for preventing and/or treating diseases which are pathophysiologically related to ghrelin receptor in a subject, comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or adduct thereof, and one or more pharmaceutically acceptable excipients.
(FR)La présente invention concerne des composés, des compositions et des procédés pour la prévention et/ou le traitement de maladies qui sont médiées de façon physiopathologique par le récepteur de ghréline. Les composés ont la formule générale (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)