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1. (WO2012115987) Methods for Treating and Preventing Cardiac Dysfunction in Septic Shock
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/115987    International Application No.:    PCT/US2012/025983
Publication Date: 30.08.2012 International Filing Date: 21.02.2012
IPC:
A61K 9/00 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 535 West 116th Street New York City, New York 10027 (US) (For All Designated States Except US).
GOLDBERG, Ira J. [US/US]; (US) (For US Only).
DROSATOS, Konstantinos [GR/US]; (US) (For US Only)
Inventors: GOLDBERG, Ira J.; (US).
DROSATOS, Konstantinos; (US)
Agent: EVANS, Judith; Evans & Molinelli PLLC P.O. Box 231 Manassas, VA 20108 (US)
Priority Data:
61/445,002 21.02.2011 US
Title (EN) Methods for Treating and Preventing Cardiac Dysfunction in Septic Shock
(FR) MÉTHODES DE TRAITEMENT ET DE PRÉVENTION DU DYSFONCTIONNEMENT CARDIAQUE DANS UN CHOC SEPTIQUE
Abstract: front page image
(EN)Cardiac dysfunction during sepsis is due, at least in part, to cardiac energy deficiency. It has been discovered that lipopolysaccharide (LPS)-mediated cardiac dysfunction is prevented or treated by treatments that improve FA oxidation (FAO), despite the persistence of inflammation. The present invention relates to methods for increasing or maintaining cardiac function in a subject, by administering to the subject a therapeutically effective amount of an agent that increases fatty acid oxidation in the heart.
(FR)Le dysfonctionnement cardiaque durant la sepsie est dû, au moins en partie, à une déficience en énergie cardiaque. On a découvert qu'il est possible de prévenir ou de traiter le dysfonctionnement cardiaque induit par les lipopolysaccharides par des traitements améliorant l'oxydation des acides gras, malgré la persistance d'une inflammation. La présente invention porte sur des procédés permettant d'accroître ou de maintenir la fonction cardiaque chez un sujet, par l'administration audit sujet d'une quantité thérapeutiquement efficace d'un agent qui augmente l'oxydation des acides gras dans le cœur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)