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1. (WO2012115578) SYNTHESIS OF FLG
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/115578    International Application No.:    PCT/SE2012/050183
Publication Date: 30.08.2012 International Filing Date: 20.02.2012
IPC:
C07D 307/20 (2006.01), C07H 19/173 (2006.01)
Applicants: MEDIVIR AB [SE/SE]; Box 1086 S-141 22 Huddinge (SE) (For All Designated States Except US).
KALAYANOV, Genadiy [UA/SE]; (SE) (For US Only)
Inventors: KALAYANOV, Genadiy; (SE)
Priority Data:
1150142-6 21.02.2011 SE
Title (EN) SYNTHESIS OF FLG
(FR) SYNTHÈSE DE FLG
Abstract: front page image
(EN)The present invention concerns the synthesis of substantially anomerically pure 2,3-dideoxy-3- fluoro-5-0-(4-phenylbenzoyl)-a-D-erythropentofuranosyl chloride from an α/β-mixture of the corresponding methyl glycoside. The method of the invention provides the pure a-chloride without the need of anomeric separation. The α-chloride thus achieved is suitable for use as glycosyl donor in the preparation of 2',3'-dideoxy-3'-fluoro nucleosides. In particular, the preparation of 2',3'-dideoxy-3 '-fluoroguanosine, FLG, using an α/β-mixture of the methyl glycoside without the need of anomeric separation is disclosed.
(FR)La présente invention porte sur la synthèse de chlorure de 2,3-didésoxy-3-fluoro-5-O-(4-phénylbenzoyl)-α-D-érythropentofuranosyle pratiquement pur de point de vue des anomères à partir d'un mélange α/β du méthylglycoside correspondant. Le procédé de l'invention permet de produire le chlorure α pur sans avoir besoin de séparer les anomères. Le chlorure α ainsi obtenu est approprié pour être utilisé comme donneur de glycosyle dans la préparation de 2',3'-didésoxy-3'-fluoronucléosides. En particulier, l'invention porte sur la préparation de 2',3'-didésoxy-3'-fluoroguanosine, FLG, à l'aide d'un mélange α/β du méthylglycoside sans avoir besoin de séparer les anomères.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)