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Pub. No.:    WO/2012/115493    International Application No.:    PCT/KR2012/001471
Publication Date: 30.08.2012 International Filing Date: 27.02.2012
G01N 33/574 (2006.01), C12Q 1/68 (2006.01), C12N 15/11 (2006.01), C12N 15/115 (2010.01)
Applicants: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTE [KR/KR]; #1270, Sa 2-dong, Sangnok-gu Ansan Si, Gyeonggi-Do 426-744 (KR) (For All Designated States Except US).
KANG, Sung Gyun [KR/KR]; (KR) (For US Only).
LEE, Hyun Sook [KR/KR]; (KR) (For US Only).
LEE, Jung-Hyun [KR/KR]; (KR) (For US Only).
KIM, Sang-Jin [KR/KR]; (KR) (For US Only).
KWON, Kae Kyong [KR/KR]; (KR) (For US Only).
YIM, Hyung-Soon [KR/KR]; (KR) (For US Only).
KIM, Yun Jae [KR/KR]; (KR) (For US Only).
HWANG, Young Ok [KR/KR]; (KR) (For US Only).
JIN, Wook [KR/KR]; (KR) (For US Only).
CHO, Yong Kyun [KR/KR]; (KR) (For US Only)
Inventors: KANG, Sung Gyun; (KR).
LEE, Hyun Sook; (KR).
LEE, Jung-Hyun; (KR).
KIM, Sang-Jin; (KR).
KWON, Kae Kyong; (KR).
YIM, Hyung-Soon; (KR).
KIM, Yun Jae; (KR).
HWANG, Young Ok; (KR).
JIN, Wook; (KR).
CHO, Yong Kyun; (KR)
Agent: YOON, Yuh-Gang; 401Ho, Pyeongchang Building Gwanak-Ro 122, Gwanak-gu Seoul 151-714 (KR)
Priority Data:
10-2011-0016983 25.02.2011 KR
(KO) 암에 대한 바이오마커 및 이를 이용한 암 진단
Abstract: front page image
(EN)The present invention relates to a kit for cancer diagnosis or prognosis analysis. An MEST according to the present invention is a marker for cancer having significantly improved accuracy and reliability. Particularly, the marker of the present invention has superior accuracy and reliability as a marker for breast cancer and liver cancer. The MEST of the present invention exhibits extremely superior accuracy and reliability as a marker for metastatic cancer. Moreover, according to the present invention, early cancer diagnosis and prognostic determination may be enabled in a very specific manner from a biological sample (for example, blood or serum) using the MEST, the expression of which specifically increases only in the cells and tissue of a cancer patient.
(FR)Cette invention concerne une trousse d'analyse diagnostique ou pronostique du cancer. Un MEST selon l'invention est un marqueur pour le cancer ayant une précision et une fiabilité significativement améliorées. En particulier, le marqueur selon l'invention a une précision et une fiabilité supérieures comme marqueur pour le cancer du sein et le cancer du foie. Le MEST selon l'invention manifeste une précision et une fiabilité très supérieures comme marqueur pour les cancers métastasiques. De plus, selon l'invention, la détermination précoce d'un diagnostic et d'un pronostic de cancer est possible d'une manière très spécifique à partir d'un échantillon biologique (par exemple, sang ou sérum) à l'aide du MEST, dont l'expression n'augmente spécifiquement que dans les cellules et les tissus d'un patient atteint d'un cancer.
(KO)본 발명은 암 진단 또는 예후 분석용 키트에 관한 것이다. 본 발명에서의 MEST는 암에 대한 마커로서의 정확성 및 신뢰도가 크게 개선된 마커이다. 특히, 본 마커는 유방암과 간암에 대한 마커로서의 정확성 및 신뢰도가 우수하다. 본 발명에서의 MEST는 전이암에 대한 마커에 있어서 매우 우수한 정확성과 신뢰도를 나타낸다. 또한, 본 발명은 암 환자의 세포 및 조직에서만 특이적으로 발현이 증가되는 MEST을 이용하여 생물학적 시료(예컨대, 혈액이나 혈청)로부터 매우 특이적으로 암의 조기 진단 및 예후를 판정할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)