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1. (WO2012115402) CRYSTALLINE FORM OF DOCETAXEL AND PROCESS FOR PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/115402    International Application No.:    PCT/KR2012/001238
Publication Date: 30.08.2012 International Filing Date: 20.02.2012
IPC:
C07D 305/14 (2006.01), A61K 31/337 (2006.01), A61P 35/00 (2006.01)
Applicants: DONG-A ST CO., LTD. [KR/KR]; (Yongdu-dong) 64, Cheonho-daero Dongdaemun-gu Seoul 130-823 (KR) (For All Designated States Except US).
SUNG, Si-Young [KR/KR]; (KR) (For US Only).
SON, Byoung-Hwa [KR/KR]; (KR) (For US Only).
RYU, Ki-Moon [KR/KR]; (KR) (For US Only).
KIM, Moon-Sung [KR/KR]; (KR) (For US Only).
KIM, Dong-Sung [KR/KR]; (KR) (For US Only).
KIM, Soon-Hoe [KR/KR]; (KR) (For US Only)
Inventors: SUNG, Si-Young; (KR).
SON, Byoung-Hwa; (KR).
RYU, Ki-Moon; (KR).
KIM, Moon-Sung; (KR).
KIM, Dong-Sung; (KR).
KIM, Soon-Hoe; (KR)
Agent: ROH, Jae-Chull; (Yeoksam-dong, Halla Building) Way With Roh Patent & Law Office, 4F. 30, Teheran-ro 25-gil, Gangnam-gu Seoul 135-909 (KR)
Priority Data:
10-2011-0015463 22.02.2011 KR
Title (EN) CRYSTALLINE FORM OF DOCETAXEL AND PROCESS FOR PREPARATION THEREOF
(FR) FORME CRISTALLINE DU DOCÉTAXEL ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
Abstract: front page image
(EN)The present invention relates to a novel anhydrous crystalline form of docetaxel. The novel anhydrous crystalline form of docetaxel according to the present invention is significant since it solves drawbacks the prior art such as stability and accompanying its relative substances increase. Moreover, the present invention provides a process for preparing the anhydrous crystalline form of docetaxel, which can solve the problems such as low yield, long processing time and low purity of the prior art. Also, the present invention provides a process for preparing the crystalline form of docetaxel trihydrates, which can solve the problems such as low yield, difficult reaction condition, long reaction time and time of drying. Therefore the crystalline form of docetaxel trihydrates is produced with the high yield in the mild condition by the process for preparing it.
(FR)La présente invention concerne une nouvelle forme cristalline anhydre du docétaxel. La nouvelle forme cristalline anhydre du docétaxel selon la présente invention est importante car elle résout les inconvénients de l'art antérieur tels que stabilité et augmentation des substances associées. De plus, la présente invention concerne un procédé de préparation de la forme cristalline anhydre du docétaxel qui peut résoudre les problèmes tels que faible rendement, temps de traitement long et faible pureté de l'art antérieur. Aussi, la présente invention concerne un procédé de préparation de la forme cristalline de trihydrates de docétaxel, qui peut résoudre les problèmes tels que faible rendement, conditions de réaction difficiles, temps de réactions et temps de séchage longs. Par conséquent, la forme cristalline des trihydrates de docétaxel est produite à haut rendement en conditions légères par son procédé de préparation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)