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1. (WO2012115097) GLYCINE TRANSPORT INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/115097    International Application No.:    PCT/JP2012/054110
Publication Date: 30.08.2012 International Filing Date: 21.02.2012
IPC:
C07D 401/04 (2006.01), A61K 31/4439 (2006.01), A61K 31/444 (2006.01), A61K 31/506 (2006.01), A61P 25/00 (2006.01), A61P 25/04 (2006.01), A61P 25/16 (2006.01), A61P 25/18 (2006.01), A61P 25/20 (2006.01), A61P 25/22 (2006.01), A61P 25/24 (2006.01), A61P 25/28 (2006.01), A61P 25/30 (2006.01), A61P 43/00 (2006.01), C07D 401/14 (2006.01), C07D 413/14 (2006.01), C07D 417/14 (2006.01)
Applicants: TAISHO PHARMACEUTICAL CO., LTD. [JP/JP]; 24-1, Takada 3-chome, Toshima-ku, Tokyo 1708633 (JP) (For All Designated States Except US).
MORIYA, Minoru [JP/JP]; (JP) (For US Only).
OHTA, Hiroshi [JP/JP]; (JP) (For US Only).
YAMAMOTO, Shuji [JP/JP]; (JP) (For US Only).
ABE, Kumi [JP/JP]; (JP) (For US Only).
ARAKI, Yuko [JP/JP]; (JP) (For US Only).
SUN, Xiang-Min [CN/JP]; (JP) (For US Only).
WAKASUGI, Daisuke [JP/JP]; (JP) (For US Only)
Inventors: MORIYA, Minoru; (JP).
OHTA, Hiroshi; (JP).
YAMAMOTO, Shuji; (JP).
ABE, Kumi; (JP).
ARAKI, Yuko; (JP).
SUN, Xiang-Min; (JP).
WAKASUGI, Daisuke; (JP)
Agent: ONO, Shinjiro; YUASA AND HARA, Section 206, New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-ku, Tokyo 1000004 (JP)
Priority Data:
2011-035169 21.02.2011 JP
Title (EN) GLYCINE TRANSPORT INHIBITOR
(FR) INHIBITEUR DE TRANSPORT DE GLYCINE
(JA) グリシントランスポーター阻害物質
Abstract: front page image
(EN)The present invention relates to a novel compound represented by formula [I] or a pharmacologically-permitted salt thereof. This compound, on the basis of the glycine-uptake-inhibiting effect thereof, is useful in the prevention or therapy of disorders such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobias, acute stress disorder, and the like), depression, drug dependence, seizures, tremors, pain, Parkinson's disease, attention-deficit hyperactivity disorder, bipolar disorder, eating disorders, or sleep disorders.
(FR)La présente invention concerne un nouveau composé représenté par la formule [I] ou un sel pharmacologiquement acceptable de celui-ci. Ce composé, sur la base de son effet d'inhibition d'absorption de glycine, est utile dans la prévention ou la thérapie de troubles tels que la schizophrénie, la maladie d'Alzheimer, le déficit cognitif, la démence, les troubles anxieux (trouble anxieux généralisé, trouble panique, trouble obsessivo-compulsif, trouble de l'anxiété sociale, trouble de stress post-traumatique, phobies spécifiques, trouble de stress aigu et similaires), la dépression, la pharmacodépendance, les crises, les tremblements, la douleur, la maladie de Parkinson, le trouble d'hyperactivité avec déficit de l'attention, le trouble bipolaire, les troubles de l'alimentation ou les troubles du sommeil.
(JA) 本発明は、新規な式[I]化合物又はその医薬上許容される塩に関し、本発明の化合物は、グリシン取り込み阻害作用に基づいた統合失調症、アルツハイマー病、認知機能障害、認知症、不安障害(全般性不安障害、パニック障害、強迫性障害、社会不安障害、外傷後ストレス障害、特定の恐怖症、急性ストレス障害等)、うつ病、薬物依存、痙攣、振戦、疼痛、パーキンソン病、注意欠陥・多動性障害、双極性障害、摂食障害、又は睡眠障害等の疾患の予防又は治療に有用である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)