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1. (WO2012114926) THIOAMIDE COMPOUND, METHOD FOR PRODUCING THIOAMIDE COMPOUND, METHOD FOR PRODUCING [(4R,6R)-6-AMINOETHYL-1,3-DIOXANE-4-YL]ACETATE DERIVATIVE, AND METHOD FOR PRODUCING ATORVASTATIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/114926    International Application No.:    PCT/JP2012/053323
Publication Date: 30.08.2012 International Filing Date: 14.02.2012
IPC:
C07C 327/42 (2006.01), A61K 31/40 (2006.01), A61P 3/06 (2006.01), A61P 13/08 (2006.01), A61P 19/10 (2006.01), A61P 25/28 (2006.01), C07D 207/34 (2006.01), C07F 7/18 (2006.01), C07B 61/00 (2006.01)
Applicants: Microbial Chemistry Research Foundation [JP/JP]; 14-23, Kamiosaki 3-chome, Shinagawa-ku, Tokyo 1410021 (JP) (For All Designated States Except US).
SHIBASAKI, Masakatsu [JP/JP]; (JP) (For US Only).
KUMAGAI, Naoya [JP/JP]; (JP) (For US Only)
Inventors: SHIBASAKI, Masakatsu; (JP).
KUMAGAI, Naoya; (JP)
Agent: HIROTA, Koichi; HIROTA, NAGARE & ASSOCIATES, 4th Floor, Shinjuku TR Bldg., 2-2-13, Yoyogi, Shibuya-ku, Tokyo 1510053 (JP)
Priority Data:
2011-035006 21.02.2011 JP
Title (EN) THIOAMIDE COMPOUND, METHOD FOR PRODUCING THIOAMIDE COMPOUND, METHOD FOR PRODUCING [(4R,6R)-6-AMINOETHYL-1,3-DIOXANE-4-YL]ACETATE DERIVATIVE, AND METHOD FOR PRODUCING ATORVASTATIN
(FR) COMPOSÉ DE THIOAMIDE, PROCÉDÉ DE PRODUCTION D'UN COMPOSÉ DE THIOAMIDE, PROCÉDÉ DE PRODUCTION D'UN DÉRIVÉ D'ACÉTATE DE [(4R,6R)-6-AMINOÉTHYL- 1,3-DIOXANE-4-YLE], ET PROCÉDÉ DE PRODUCTION D'ATORVASTATINE
(JA) チオアミド化合物、チオアミド化合物の製造方法、[(4R,6R)-6-アミノエチル-1,3-ジオキサン-4-イル]アセテート誘導体の製造方法、及びアトルバスタチンの製造方法
Abstract: front page image
(EN)Provided is the thioamide compound represented by general formula (1). In general formula (1): R1 represents -OR11 or -NR12R13; R2 and R3 each independently represent a protecting group of an amide group or a hydrogen atom; R11 represents a protecting group of a hydroxide group or a hydrogen atom; and R12 and R13 each independently represent a protecting group of an amino group or a hydrogen atom (moreover, R12 and R13 may together form a ring-structured protecting group).
(FR)Cette invention concerne un composé de thioamide représenté par la formule générale (1). Dans la formule générale (1) : R1 représente -OR11 ou -NR12R13 ; R2 et R3 représentent chacun indépendamment un groupe de protection d'un groupe amide ou un atome d'hydrogène ; R11 représente un groupe de protection d'un groupe hydroxyde ou un atome d'hydrogène ; et R12 et R13 représentent chacun indépendamment un groupe de protection d'un groupe amino ou un atome d'hydrogène (R12 et R13 ensemble pouvant, en plus, former un groupe de protection à structure de cycle).
(JA) 下記一般式(1)で表されるチオアミド化合物。 ただし、前記一般式(1)中、Rは、-OR11、及び-NR1213のいずれかを表す。R及びRは、それぞれ独立に、アミド基の保護基及び水素原子のいずれかを表す。前記R11は、水酸基の保護基及び水素原子のいずれかを表す。前記R12及び前記R13は、それぞれ独立に、アミノ基の保護基及び水素原子のいずれかを表す(なお、前記R12及び前記R13は、一緒になって環構造の保護基を形成していてもよい)。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)