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1. (WO2012114342) FLUMAZENIL COMPLEXES, COMPOSITIONS COMPRISING SAME AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/114342    International Application No.:    PCT/IL2012/050060
Publication Date: 30.08.2012 International Filing Date: 23.02.2012
IPC:
C07D 245/06 (2006.01)
Applicants: COERULEUS LTD. [IL/IL]; Industrial Zone P.O. Box 12 12900 Katzrin (IL) (For All Designated States Except US).
AMSELEM, Shimon [IL/IL]; (IL) (For US Only)
Inventors: AMSELEM, Shimon; (IL)
Agent: WEBB & CO.; P.O. Box 2189 76121 Rehovot (IL)
Priority Data:
61/445,559 23.02.2011 US
Title (EN) FLUMAZENIL COMPLEXES, COMPOSITIONS COMPRISING SAME AND USES THEREOF
(FR) COMPLEXES DE FLUMAZÉNIL, COMPOSITIONS LES COMPRENANT ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides soluble complexes of flumazenil, methods for the preparation thereof, pharmaceutical compositions comprising same and use of said compositions for alleviating or counteracting the various types of hypersomnia, drowsiness, residual effects associated with the administration of sleep/hypnotic drugs, alcohol intoxication or hepatic encephalopathy. The present invention is based in part on the unexpected discovery that flumazenil complexes are more soluble than flumazenil alone.
(FR)La présente invention concerne des complexes solubles de flumazénil, des procédés pour leur préparation, des compositions pharmaceutiques les comprenant et l'utilisation desdites compositions pour atténuer ou contrecarrer les divers types d'hypersomnie, la somnolence, les effets secondaires associés à l'administration de médicaments somnifères/hypnotiques, l'intoxication alcoolique ou l'encéphalopathie hépatique. La présente invention est fondée en partie sur la découverte inattendue que les complexes de flumazénil sont plus solubles que le flumazénil seul.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)