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1. (WO2012113921) RAPID SELECTION METHOD FOR HIV GP-120 VARIANTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/113921    International Application No.:    PCT/EP2012/053185
Publication Date: 30.08.2012 International Filing Date: 24.02.2012
IPC:
C07K 14/16 (2006.01), A61K 39/21 (2006.01), G01N 33/569 (2006.01), G01N 33/68 (2006.01), C12N 15/10 (2006.01)
Applicants: LABORATORIOS DEL DR. ESTEVE, S.A. [ES/ES]; Avda. Mare de Déu de Montserrat, 221 E-08041 Barcelona (ES) (For All Designated States Except US).
FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA - CAIXA [ES/ES]; Hospital Universitari Germans Trias i Pujol Carretera de Canyet, s/n E-08916 Badalona (ES) (For All Designated States Except US).
YUSTE HERRANZ, María Eloísa [ES/ES]; (ES) (For US Only).
SÁNCHEZ MERINO, Víctor [ES/ES]; (ES) (For US Only).
FERREIRA, Carolina [PT/ES]; (ES) (For US Only)
Inventors: YUSTE HERRANZ, María Eloísa; (ES).
SÁNCHEZ MERINO, Víctor; (ES).
FERREIRA, Carolina; (ES)
Agent: ALCONADA RODRÍGUEZ, Agustín; Abg Patentes, S.L. Avda. de Burgos 16D Edificio Euromor E-28036 Madrid (ES)
Priority Data:
11382051.8 25.02.2011 EP
61/446,595 25.02.2011 US
Title (EN) RAPID SELECTION METHOD FOR HIV GP-120 VARIANTS
(FR) PROCÉDÉ DE SÉLECTION RAPIDE DE VARIANTS DE LA GP-120 DU VIH
Abstract: front page image
(EN)The invention relates to a method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized HIV gp120 variants of a surface polypeptide displayed to said neutralizing antibodies. The invention relates as well to the use of the HIV gp120 immunogens isolated according to the RIS method of the invention in medicine for the treatment of diseases caused by a virus and in diagnosis for the identification of neutralizing antibodies in a patient.
(FR)Cette invention concerne un procédé de sélection rapide d'immunogènes (RIS) qui se base sur la liaison d'une banque de virus recombinés contenant des variants de la gp120 du VIH randomisés constitués d'un polypeptide de surface présenté auxdits anticorps neutralisants. Cette invention concerne également l'utilisation des immunogènes gp120 du VIH isolés par le procédé RIS selon l'invention en médecine pour traiter les maladies d'origine virale et dans les applications diagnostiques destinées à identifier des anticorps neutralisants chez un patient.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)