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1. (WO2012113863) METHOD OF PRODUCTION OF SIALYLATED ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/113863    International Application No.:    PCT/EP2012/053065
Publication Date: 30.08.2012 International Filing Date: 23.02.2012
IPC:
C07K 16/18 (2006.01)
Applicants: SANOFI [FR/FR]; 54 rue La Boétie F-75008 Paris (FR) (For All Designated States Except US).
BLANCHE, Francis [FR/FR]; (FR) (For US Only).
CAMERON, Béatrice [FR/FR]; (FR) (For US Only).
GENET, Bruno [FR/FR]; (FR) (For US Only).
SOUBRIER, Fabrienne [FR/FR]; (FR) (For US Only)
Inventors: BLANCHE, Francis; (FR).
CAMERON, Béatrice; (FR).
GENET, Bruno; (FR).
SOUBRIER, Fabrienne; (FR)
Agent: RIBARD, Carin; c/o Sanofi Patent Department 54 rue La Boétie F-75008 Paris (FR)
Priority Data:
11305200.5 24.02.2011 EP
11306090.9 01.09.2011 EP
Title (EN) METHOD OF PRODUCTION OF SIALYLATED ANTIBODIES
(FR) PROCÉDÉ DE PRODUCTION D'ANTICORPS SIALYLÉS
Abstract: front page image
(EN)The present invention relates to a method for producing an IgG antibody, wherein at least 80 % of the said antibody comprises a complex, bi-antennary oligosaccharide, which contains two sialic acid residues, attached to the Fc domain of the antibody. The said method comprises the steps of introducing a mutation in the Fc domain of the antibody, and expressing the mutant antibody in a cell which expresses a galactosyltransferase and a sialyltransferase activity.
(FR)L'invention concerne un procédé de production d'un anticorps IgG, au moins 80 % de cet anticorps comprenant un oligosaccharide biantennulaire complexe qui contient deux résidus d'acide sialique, fixés au domaine Fc de l'anticorps. Ce procédé comprend les étapes consistant à: introduire une mutation dans le domaine Fc de l'anticorps, et exprimer l'anticorps mutant dans une cellule qui exprime une activité de galactosyltransférase et de sialyltransférase.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)