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1. (WO2012113775) ANKYRIN G AND MODULATORS THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/113775    International Application No.:    PCT/EP2012/052907
Publication Date: 30.08.2012 International Filing Date: 21.02.2012
IPC:
A61K 38/17 (2006.01), C07K 16/18 (2006.01), A61K 39/00 (2006.01), G01N 33/53 (2006.01), A61P 25/28 (2006.01)
Applicants: University of Zurich [CH/CH]; Rämistrasse 71 CH-8006 Zurich (CH) (For All Designated States Except US).
SANTUCCIONE CHADHA, Antonella [IT/CH]; (CH) (For US Only).
MERLINI, Mario [NL/US]; (US) (For US Only).
NITSCH, Roger [DE/CH]; (CH) (For US Only).
GRIMM, Jan [DE/CH]; (CH) (For US Only).
HOCK, Christoph [DE/CH]; (CH) (For US Only)
Inventors: SANTUCCIONE CHADHA, Antonella; (CH).
MERLINI, Mario; (US).
NITSCH, Roger; (CH).
GRIMM, Jan; (CH).
HOCK, Christoph; (CH)
Agent: STEINECKE, Peter; P.O. Box 11 40 52412 Jülich (DE)
Priority Data:
11001406.5 21.02.2011 EP
61/445,447 22.02.2011 US
Title (EN) ANKYRIN G AND MODULATORS THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
(FR) ANKYRINE G ET SES MODULATEURS POUR LE TRAITEMENT DE TROUBLES NEURODÉGÉNÉRATIFS
Abstract: front page image
(EN)The present invention generally relates to the technical field of medicine, in particular to the field of neurodegenerative, neurological and protein misfolding disorders such as amyloidosis. By establishing a role of ankG in APP processing the method of the present invention provides a new insight into the the role of ankG in AD pathology and provides ankG as a target, drug, diagnostic agent and particularly as a vaccine in the treatment and diagnosis of the pathogenesis of Alzheimer's disease (AD).
(FR)La présente invention concerne généralement le domaine technique de la médecine, notamment le domaine des troubles neurodégénératifs, neurologiques et de mauvais repliement des protéines tels que l'amyloïdose. En établissant un rôle de l'ankG dans le processus de l'APP, le procédé de la présente invention offre un nouveau regard sur le rôle de l'ankG dans la pathologie de la MD et propose l'ankG en tant que cible, médicament, agent de diagnostic et notamment en tant que vaccin dans le traitement et le diagnostic de la pathogenèse de la maladie d'Alzheimer (MD).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)