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1. (WO2012112982) HYDROGEL ENCAPSULATED CELLS AND ANTI-INFLAMMATORY DRUGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/112982    International Application No.:    PCT/US2012/025806
Publication Date: 23.08.2012 International Filing Date: 20.02.2012
IPC:
A61K 9/16 (2006.01), A61K 9/50 (2006.01), A61K 31/12 (2006.01), A61K 31/573 (2006.01), C12N 5/00 (2006.01)
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; One Cambridge Center, Kendall Square Cambridge, MA 02142 (US) (For All Designated States Except US).
ANDERSON, Daniel G. [US/US]; (US) (For US Only).
LANGER, Robert S. [US/US]; (US) (For US Only).
DANG, Tram T. [SG/US]; (US) (For US Only)
Inventors: ANDERSON, Daniel G.; (US).
LANGER, Robert S.; (US).
DANG, Tram T.; (US)
Agent: PABST, Patrea, L.; Pabst Patent Group LLP 1545 Peachtree Street, N.E. Suite 320 Atlanta, GA 30309 (US)
Priority Data:
61/444,206 18.02.2011 US
Title (EN) HYDROGEL ENCAPSULATED CELLS AND ANTI-INFLAMMATORY DRUGS
(FR) CELLULES ENCAPSULÉES DANS DE L'HYDROGEL ET MÉDICAMENTS ANTI-INFLAMMATOIRES
Abstract: front page image
(EN)A composition containing biocompatible hydrogel encapsulating mammalian cells and anti-inflammatory drugs is disclosed. The encapsulated cells have reduced fibrotic overgrowth after implantation in a subject. The compositions contain a biocompatible hydrogel having encapsulated therein mammalian cells and anti-inflammatory drugs or polymeric particles loaded with anti-inflammatory drugs. The anti-inflammatory drugs are released from the composition after transplantation in an amount effective to inhibit fibrosis of the composition for at least ten days. Methods for identifying and selecting suitable anti-inflammatory drug-loaded particles to prevent fibrosis of encapsulated cells are also described. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
(FR)La présente invention concerne une composition contenant de l'hydrogel biocompatible encapsulant des cellules mammifères, et des médicaments anti-inflammatoires. Lesdites cellules encapsulées présentent un accroissement fibreux réduit après leur implantation dans un sujet. Les compositions de l'invention contiennent un hydrogel biocompatible comportant des cellules mammifères encapsulées à l'intérieur, et des médicaments anti-inflammatoires ou des particules polymères chargées de médicaments anti-inflammatoires. Lesdits médicaments anti-inflammatoires sont libérés de la composition après transplantation, dans une quantité efficace pour inhiber la fibrose de la composition pendant au moins dix jours. L'invention porte en outre sur des procédés d'identification et de sélection de particules chargées de médicament anti-inflammatoire pour prévenir la fibrose de cellules encapsulées. L'invention a également trait à des méthodes de traitement d'une maladie chez un sujet qui impliquent l'administration d'une quantité thérapeutiquement efficace des cellules encapsulées de l'invention au sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)