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Machine translation
1. (WO2012112933) DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/112933    International Application No.:    PCT/US2012/025712
Publication Date: 23.08.2012 International Filing Date: 17.02.2012
IPC:
C12N 5/00 (2006.01)
Applicants: THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road, Mail TPC-8 La Jolla, California 92037 (US) (For All Designated States Except US).
IRM LLC; 131 Front Street P.O. Box HM 2899 HM LX Hamilton (BM) (For All Designated States Except US).
SCHULTZ, Peter [US/US]; (US) (For US Only).
LAIRSON, Luke [CA/US]; (US) (For US Only).
DESHMUKH, Vishal [IN/US]; (US) (For US Only).
LYSSIOTIS, Costas [US/US]; (US) (For US Only)
Inventors: SCHULTZ, Peter; (US).
LAIRSON, Luke; (US).
DESHMUKH, Vishal; (US).
LYSSIOTIS, Costas; (US)
Agent: FLANAGAN, Lisa Dornbach; Kilpatrick Townsend & Stockton LLP Two Embarcadero Center, Eighth Floor San Francisco, California 94111-3834 (US)
Priority Data:
61/444,666 18.02.2011 US
Title (EN) DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE
(FR) DIFFÉRENCIATION DIRIGÉE DE CELLULES PRÉCURSEURS D'OLIGODENDROCYTES VERS UN DESTIN CELLULAIRE MYÉLINISANT
Abstract: front page image
(EN)The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.
(FR)La présente invention concerne des procédés d'induction de la différenciation de cellules progénitrices d'oligodendrocytes vers un destin cellulaire myélinisant mature avec un agent de modulation de récepteur de neurotransmetteur. La présente invention concerne en outre des procédés de stimulation d'une augmentation de la myélinisation chez un sujet nécessitant celle-ci par administration dudit agent de modulation de récepteur de neurotransmetteur. La présente invention concerne en outre des procédés de traitement d'un sujet ayant une maladie démyélinisante en utilisant un agent de modulation de récepteur de neurotransmetteur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)