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1. (WO2012112919) STROMAL DERIVED FACTOR INHIBITION AND CXCR4 BLOCKADE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/112919    International Application No.:    PCT/US2012/025686
Publication Date: 23.08.2012 International Filing Date: 17.02.2012
IPC:
A61K 31/497 (2006.01), A61K 31/135 (2006.01), A61K 39/00 (2006.01), A61P 19/00 (2006.01), A61P 21/00 (2006.01)
Applicants: RHODE ISLAND HOSTPITAL [US/US]; 593 Eddy Street Providence, RI 02903 (US) (For All Designated States Except US).
BLAINE, Theodore, A. [US/US]; (US) (For US Only)
Inventors: BLAINE, Theodore, A.; (US)
Agent: BEATTIE, Ingrid, A.; Mintz Levin Cohn Ferris Glovsky And Popeo, P.C. One Financial Center Boston, MA 02111 (US)
Priority Data:
61/444,011 17.02.2011 US
Title (EN) STROMAL DERIVED FACTOR INHIBITION AND CXCR4 BLOCKADE
(FR) INHIBITION DU FACTEUR ISSU DU STROMA ET BLOCAGE DE CXCR4
Abstract: front page image
(EN)The invention relates to inhibition of SDF-la expression in subacromial bursa cells by CXCR-4 inhibitors. Bursal cell migration in response to SDF-α stimulation is also decreased in the presence of CXCR4 inhibitors. Accordingly, provided are methods for treating or ameliorating a musculoskeletal disorder.
(FR)L'invention concerne l'inhibition de l'expression de SDF-1a dans les cellules bursales sous-acromiales par des inhibiteurs de CXCR4. La migration des cellules bursales en réponse à une stimulation de SDF-α est également réduite en présence d'inhibiteurs de CXCR-4. L'invention concerne donc également des méthodes de traitement ou d'amélioration de troubles musculo-squelettiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)