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1. (WO2012112687) METHODS OF PREPARATION OF CONJUGATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/112687    International Application No.:    PCT/US2012/025257
Publication Date: 23.08.2012 International Filing Date: 15.02.2012
IPC:
A61K 47/48 (2006.01), C07D 487/04 (2006.01), C07D 519/00 (2006.01), A61P 35/00 (2006.01)
Applicants: IMMUNOGEN, INC. [US/US]; 830 Winter Street Waltham, MA 02451 (US) (For All Designated States Except US).
FISHKIN, Nathan [US/US]; (US) (For US Only).
MILLER, Michael [US/US]; (US) (For US Only).
LI, Wei [CN/US]; (US) (For US Only).
SINGH, Rajeeva [US/US]; (US) (For US Only)
Inventors: FISHKIN, Nathan; (US).
MILLER, Michael; (US).
LI, Wei; (US).
SINGH, Rajeeva; (US)
Agent: DAVIS, Steven, G.; McCarter English, LLP 265 Franklin Street Boston, MA 02110 (US)
Priority Data:
61/443,062 15.02.2011 US
61/443,092 15.02.2011 US
61/483,499 06.05.2011 US
Title (EN) METHODS OF PREPARATION OF CONJUGATES
(FR) PROCÉDÉS DE PRÉPARATION DE CONJUGUÉS
Abstract: front page image
(EN)The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.
(FR)La présente invention concerne des procédés de préparation d'un conjugué d'un agent liant les cellules et d'un médicament (comme un composé cytotoxique). Les procédés comprennent l'utilisation d'un composé réactif avec les imines pour permettre des conjugaisons efficaces de composés cytotoxiques avec des agents liant les cellules.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)