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1. (WO2012112623) RXRG MODULATORS FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/112623    International Application No.:    PCT/US2012/025137
Publication Date: 23.08.2012 International Filing Date: 14.02.2012
IPC:
A61K 31/5513 (2006.01)
Applicants: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH [US/US]; 1275 York Avenue New York, NY 10021 (US) (For All Designated States Except US).
XU, Xiaoliang [CN/US]; (US) (For US Only).
JHANWAR, Suresh [US/US]; (US) (For US Only)
Inventors: XU, Xiaoliang; (US).
JHANWAR, Suresh; (US)
Agent: REARICK, John, P.; Choate, Hall & Stewart LLP Two International Place Boston, MA 02110 (US)
Priority Data:
61/442,699 14.02.2011 US
Title (EN) RXRG MODULATORS FOR THE TREATMENT OF CANCER
(FR) MODULATEURS DES RXRG DESTINÉS À TRAITER LE CANCER
Abstract: front page image
(EN)The present invention provides methods for treating cancer using modulators of retinoid X receptor gamma (RXRG). The ability of RXRG antagonists to disrupt the association of complexes comprising RXRG is demonstrated. In certain embodiments, the invention provides methods of inhibiting proliferation of cancer cells with a compound described herein. In some embodiments, a compound used in accordance with the provided method is a retinoid X receptor gamma (RXRG) antagonist. In certain embodiments, the invention provides methods of inhibiting proliferation of cancer cells with KRAS, EGFR, or PTEN mutations with a RXRG antagonist.
(FR)La présente invention concerne des procédés de traitement du cancer utilisant des modulateurs des récepteurs gamma des rétinoïdes X (RXRG). La capacité des antagonistes des RXRG à rompre l'association des complexes comprenant les RXRG est démontrée ici.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)