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Pub. No.:    WO/2012/112492    International Application No.:    PCT/US2012/024974
Publication Date: 23.08.2012 International Filing Date: 14.02.2012
C07B 59/00 (2006.01), C07C 59/01 (2006.01), A61K 31/19 (2006.01), A61K 31/22 (2006.01), A61P 21/00 (2006.01), A61P 25/02 (2006.01), A61P 25/20 (2006.01), C07C 69/67 (2006.01)
Applicants: CONCERT PHARMACEUTICALS INC. [US/US]; 99 Hayden Avenue Lexington, MA 02421 (US) (For All Designated States Except US).
TUNG, Roger, D. [US/US]; (US) (For US Only).
MORGAN, Adam [US/US]; (US) (For US Only).
SILVERMAN, I., Robert [US/US]; (US) (For US Only)
Inventors: TUNG, Roger, D.; (US).
MORGAN, Adam; (US).
SILVERMAN, I., Robert; (US)
Agent: DAVIS, Steven, G.; Mccarter & English, LLP 265 Franklin Street Boston, MA 02110 (US)
Priority Data:
61/442,451 14.02.2011 US
61/484,296 10.05.2011 US
Abstract: front page image
(EN)This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
(FR)La présente invention a pour objet de nouveaux dérivés de l'acide 4-hydroxybutyrique et leurs promédicaments, et des sels pharmaceutiquement acceptables de ceux-ci. Cette invention concerne aussi des compositions pharmaceutiques comprenant un composé selon cette invention et l'utilisation de telles compositions dans des méthodes de traitement de la narcolepsie, de la fibromyalgie, d'autres troubles ou affections qui sont traités avantageusement par l'amélioration du sommeil nocturne ou par l'administration d'oxybate de sodium.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)