WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012112438) ANTI-MICROBIAL AGENTS AND COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/112438    International Application No.:    PCT/US2012/024851
Publication Date: 23.08.2012 International Filing Date: 13.02.2012
IPC:
A61K 38/08 (2006.01), A61K 35/74 (2006.01), A61K 35/66 (2006.01), A61P 31/04 (2006.01), A61P 31/00 (2006.01)
Applicants: THE PENN STATE RESEARCH FOUNDATION [US/US]; 304 Old Main University Park, PA 16802 (US) (For All Designated States Except US).
POSTLE, Kathleen [US/US]; (US) (For US Only)
Inventors: POSTLE, Kathleen; (US)
Agent: DOBBELAERE, Amy, A.; 525 Okeechobee Blvd, 15th Floor West Palm Beach, FL 33401 (US)
Priority Data:
61/443,511 16.02.2011 US
61/532,729 09.09.2011 US
Title (EN) ANTI-MICROBIAL AGENTS AND COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF
(FR) COMPOSITIONS ET AGENTS ANTIMICROBIENS, ET LEURS MÉTHODES DE PRODUCTION ET D'UTILISATION
Abstract: front page image
(EN)Anti-microbial compositions for inhibiting gram-negative bacterial growth include inhibitors of one or more interactions between the bacterial proteins TonB and ExbD and/or between the bacterial proteins TolR and TolA. Methods of producing and using the anti-microbial compositions (e.g., treating gram-negative bacterial infections in a mammalian subject) are described. Novel antibiotics that target the TonB system and prevent bacterial growth are described herein.
(FR)La présente invention concerne des compositions antimicrobiennes destinées à inhiber la croissance de bactéries à Gram négatif, comprenant des inhibiteurs d'une ou de plusieurs interactions entre les protéines bactériennes TonB et ExbD et/ou entre les protéines bactériennes TolR et TolA. L'invention porte en outre sur des méthodes de production et d'utilisation desdites compositions antimicrobiennes (par exemple dans le traitement d'infections bactériennes à Gram négatif chez un sujet mammifère). L'invention a également trait à de nouveaux antibiotiques qui ciblent le système TonB et empêchent la croissance bactérienne.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)