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1. (WO2012112245) MODULATION OF PHOSPHATIDYLINOSITOL-5-PHOSPHATE-4-KINASE ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/112245    International Application No.:    PCT/US2012/021266
Publication Date: 23.08.2012 International Filing Date: 13.01.2012
IPC:
C12Q 1/48 (2006.01), C07H 21/04 (2006.01)
Applicants: BETH ISRAEL DEACONESS MEDICAL CENTER, INC. [US/US]; 330 Brookline Avenue Boston, MA 02215 (US) (For All Designated States Except US).
EMERLING, Brooke [US/US]; (US) (For US Only).
SASAKI, Atsuo [JP/US]; (US) (For US Only).
CANTLEY, Lewis, C. [US/US]; (US) (For US Only).
HUROV, Jonathan [CA/US]; (US) (For US Only)
Inventors: EMERLING, Brooke; (US).
SASAKI, Atsuo; (US).
CANTLEY, Lewis, C.; (US).
HUROV, Jonathan; (US)
Agent: BIEKER-BRADY, Kristina; Clark & Elbing LLP 101 Federal Street Boston, MA 02110 (US)
Priority Data:
61/442,622 14.02.2011 US
Title (EN) MODULATION OF PHOSPHATIDYLINOSITOL-5-PHOSPHATE-4-KINASE ACTIVITY
(FR) MODULATION DE L'ACTIVITÉ PHOSPHATIDYLINOSITOL-5-PHOSPHATE-4-KINASE
Abstract: front page image
(EN)The invention features methods for identifying compounds that modulate the activity of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K). Inhibitors of PI5P4K can be used in, for example, the treatment or prevention of cell proliferation disorders (e.g., the prevention of tumor cell growth in p53 mutated cancers).
(FR)La présente invention concerne des procédés pour identifier des composés qui modulent l'activité de phosphatidylinositol 5-phosphate 4-kinase (PI5P4K). Les inhibiteurs de PI5P4K peuvent être utilisés dans, par exemple, le traitement ou la prévention de troubles de prolifération cellulaire (par exemple, la prévention de la croissance de cellules de tumeur dans des cancers à mutation de p53).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)