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1. (WO2012112232) METHODS AND COMPOSITIONS FOR TREATING β-THALASSEMIA AND SICKLE CELL DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/112232    International Application No.:    PCT/US2012/020059
Publication Date: 23.08.2012 International Filing Date: 03.01.2012
IPC:
C07D 471/04 (2006.01), A61K 31/4745 (2006.01), A61P 7/00 (2006.01)
Applicants: ACADEMIA SINICA; 128 Academia Road Section 2, Nankang Taipei, 115 (TW) (For All Designated States Except US).
SHEN, Che-Kun, James [US/--]; (TW) (For US Only).
CHOU, Yu-Chi; (TW) (For US Only)
Inventors: SHEN, Che-Kun, James; (TW).
CHOU, Yu-Chi; (TW)
Agent: BAKER, C., Hunter; Wolf, Greenfield & Sacks,P.C. 600 Atlantic Avenue Boston, MA 02210-2206 (US)
Priority Data:
61/444,436 18.02.2011 US
Title (EN) METHODS AND COMPOSITIONS FOR TREATING β-THALASSEMIA AND SICKLE CELL DISEASE
(FR) MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE LA Β-THALASSÉMIE ET DE LA DRÉPANOCYTOSE
Abstract: front page image
(EN)The present invention provides compounds (such as compounds of formula I-a) that induce γ globin expression and pharmaceutical compositions thereof. Such compounds may have beneficial therapeutic effects. Compounds and compositions described herein may be used to treat hemoglobinopathies such as β-thalassemia and sickle cell anemia. (I-a)
(FR)La présente invention concerne des composés (tels que les composés de la formule I-a) qui induisent l'expression de γ globine, et des compositions pharmaceutiques associées. De tels composés peuvent avoir des effets thérapeutiques bénéfiques. Les composés et les compositions décrits par les présentes peuvent être utilisés pour traiter des hémoglobinopathies, telles que la β-thalassémie et la drépanocytose. R1 R6A (I-a).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)