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1. (WO2012112119) METHOD AND APPARATUS FOR ANALYZING A LIQUID SAMPLE BY RAMAN SPECTROSCOPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/112119    International Application No.:    PCT/SG2011/000065
Publication Date: 23.08.2012 International Filing Date: 16.02.2011
Chapter 2 Demand Filed:    18.04.2012    
IPC:
G01N 21/65 (2006.01), G01J 3/44 (2006.01)
Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH [SG/SG]; 1 Fusionopolis Way #20-10 Connexis Singapore 138632 (SG) (For All Designated States Except US).
NIZAMUDIN, Md.,Khalid [SG/SG]; (SG) (For US Only).
SALIM, Shaik [SG/SG]; (SG) (For US Only).
WIDJAJA, Effendi [ID/SG]; (SG) (For US Only).
LIM, Geok Hong [SG/SG]; (SG) (For US Only).
GARLAND, Marc [US/SG]; (SG) (For US Only).
AGARWAL, Ajay [IN/SG]; (SG) (For US Only).
FANG, Cheng [CN/SG]; (SG) (For US Only).
BUDDHARAJU, Kavitha, Devi [IN/SG]; (SG) (For US Only)
Inventors: NIZAMUDIN, Md.,Khalid; (SG).
SALIM, Shaik; (SG).
WIDJAJA, Effendi; (SG).
LIM, Geok Hong; (SG).
GARLAND, Marc; (SG).
AGARWAL, Ajay; (SG).
FANG, Cheng; (SG).
BUDDHARAJU, Kavitha, Devi; (SG)
Agent: WATKIN, Timothy, Lawrence, Harvey; Marks & Clerk Singapore LLP Tanjong Pagar P.O. Box 636 Singapore 910816 (SG)
Priority Data:
Title (EN) METHOD AND APPARATUS FOR ANALYZING A LIQUID SAMPLE BY RAMAN SPECTROSCOPY
(FR) PROCÉDÉ ET APPAREIL POUR L'ANALYSE D'UN ÉCHANTILLON LIQUIDE PAR SPECTROSCOPIE RAMAN
Abstract: front page image
(EN)A liquid sample containing multiple analytes is used to produce a layer on a SERS surface of an SERS substrate. Raman spectra are collected from the different locations. The Raman spectra for different locations have different ratios of signal components from the multiple respective analytes, for example because the analytes are present in different proportions at the different locations, or because the analytes interact with the SERS surface in different ways at the different locations. A self-modeling curve resolution technique such as BTEM is used to extract from the collected Raman spectra multiple pure component spectra, corresponding to the respective analyte components. The pure component spectra can be used to identify the analytes. One way of producing the inhomogenous layer is by evaporating the liquid sample. Another is by arranging for the surface of the SERS substrate to be inhomogeneous, so that an inhomogenous layer of adsorbed analytes is formed and/or such that the SERS effect itself is inhomogenous.
(FR)Selon la présente invention, un échantillon liquide contenant des analytes multiples est utilisé pour produire une couche sur une surface SERS d'un substrat SERS. Des spectres Raman sont recueillis à partir des différents emplacements. Les spectres Raman pour des emplacements différents ont des rapports différents des composantes de signal des analytes respectifs multiples, par exemple car les analytes sont présents dans des proportions différentes aux différents emplacements, ou car les analytes interagissent avec la surface SERS de manières différentes aux différents emplacements. Une technique de résolution de courbe auto-modelante telle que BTEM est utilisée pour extraire à partir des spectres Raman recueillis de multiples spectres de composants purs, correspondant aux composants d'analytes respectifs. Les spectres de composants purs peuvent être utilisés pour identifier les analytes. Une façon de produire la couche inhomogène est d'évaporer l'échantillon liquide. Une autre est de disposer la surface du substrat SERS de sorte qu'elle soit inhomogène, de sorte qu'une couche inhomogène d'analytes adsorbés soit formée et/ou de telle sorte que l'effet SERS lui-même soit inhomogène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)