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1. (WO2012111995) OXIME DERIVATIVES AS GPR119 AGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/111995    International Application No.:    PCT/KR2012/001185
Publication Date: 23.08.2012 International Filing Date: 16.02.2012
IPC:
C07D 401/14 (2006.01), C07D 401/12 (2006.01), A61K 31/4523 (2006.01), A61P 3/00 (2006.01)
Applicants: LG LIFE SCIENCES LTD. [KR/KR]; LG Gwanghwamun Bldg. 92, Sinmunno 2-ga, Jongno-gu Seoul 110-062 (KR) (For All Designated States Except US).
KIM, Young Kwan [KR/KR]; (KR) (For US Only).
JOO, Hyun Woo [KR/KR]; (KR) (For US Only).
KIM, Myoung Yeol [KR/KR]; (KR) (For US Only).
PARK, Heui Sul [KR/KR]; (KR) (For US Only).
LEE, Tae Hee [KR/KR]; (KR) (For US Only).
KWAK, Hyo Shin [KR/KR]; (KR) (For US Only).
SHIM, Dong Sup [KR/KR]; (KR) (For US Only).
CHOI, Eun Sil [KR/KR]; (KR) (For US Only)
Inventors: KIM, Young Kwan; (KR).
JOO, Hyun Woo; (KR).
KIM, Myoung Yeol; (KR).
PARK, Heui Sul; (KR).
LEE, Tae Hee; (KR).
KWAK, Hyo Shin; (KR).
SHIM, Dong Sup; (KR).
CHOI, Eun Sil; (KR)
Agent: CHOI, Kyu Pal; Halla Classic Building 4F. 824-11, Yeoksam-dong, Kangnam-gu Seoul 135-080 (KR)
Priority Data:
10-2011-0014298 17.02.2011 KR
Title (EN) OXIME DERIVATIVES AS GPR119 AGONISTS
(FR) DÉRIVÉS D'OXIME FORMANT AGONISTES DU RÉCEPTEUR GPR119
Abstract: front page image
(EN)The present invention relates to oxime derivatives, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The oxime derivatives according to the present invention act as GPR119 agonists to stimulate the secretion of insulin and promote GLP-1 formation for preventing or treating type 2 diabetes, complications of diabetes, obesity, dyslipidemia or osteoporosis.
(FR)La présente invention concerne des dérivés d'oxime, un procédé pour leur préparation, une composition pharmaceutique les comprenant et leur utilisation. Les dérivés d'oxime selon la présente invention agissent comme des agonistes du récepteur GPR119 pour stimuler la sécrétion d'insuline et favoriser la formation de GLP-1 pour prévenir ou traiter le diabète de type 2, les complications du diabète, l'obésité, la dyslipidémie ou l'ostéoporose.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)