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1. WO2012111790 - POTENTIATOR OF ANTITUMOR ACTIVITY OF CHEMOTHERAPEUTIC AGENT

Publication Number WO/2012/111790
Publication Date 23.08.2012
International Application No. PCT/JP2012/053757
International Filing Date 17.02.2012
IPC
A61K 31/198 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A23L 1/305 2006.1
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
1Foods or foodstuffs; Their preparation or treatment
29Modifying nutritive qualities of foods; Dietetic products
30containing additives
305Amino acids, peptides or proteins 
A61K 31/513 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61K 45/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61P 1/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
CPC
A23L 33/175
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
17Amino acids, peptides or proteins
175Amino acids
A23V 2002/00
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
2002Food compositions, function of food ingredients or processes for food or foodstuffs
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K 31/4412
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4412having oxo groups directly attached to the heterocyclic ring
A61K 31/513
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A61K 31/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
53having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
Applicants
  • 味の素株式会社 AJINOMOTO CO., INC. [JP]/[JP] (AllExceptUS)
  • 学校法人久留米大学 KURUME UNIVERSITY [JP]/[JP] (AllExceptUS)
  • 西谷 しのぶ NISHITANI, Shinobu [JP]/[JP] (UsOnly)
  • 矢野 博久 YANO, Hirohisa [JP]/[JP] (UsOnly)
Inventors
  • 西谷 しのぶ NISHITANI, Shinobu
  • 矢野 博久 YANO, Hirohisa
Agents
  • 高島 一 TAKASHIMA, Hajime
Priority Data
2011-03251117.02.2011JP
2011-21560529.09.2011JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) POTENTIATOR OF ANTITUMOR ACTIVITY OF CHEMOTHERAPEUTIC AGENT
(FR) POTENTIALISATEUR DE L'ACTIVITÉ ANTITUMORALE D'UN AGENT CHIMIOTHÉRAPIQUE
(JA) 化学療法剤の抗腫瘍活性増強剤
Abstract
(EN) The invention relates to an agent for potentiating the antitumor activity of a chemotherapeutic agent for cancer including cancer stem cells, comprising at least one branched-chain amino acid selected from isoleucine, leucine, and valine or a salt thereof. The invention also relates to an agent for treating cancer including cancer stem cells, comprising at least one branched-chain amino acid selected from isoleucine, leucine, and valine or a salt thereof, and a chemotherapeutic agent in combination. The invention also relates to an agent for preventing the metastasis or recurrence of cancer including cancer stem cells, comprising at least one branched-chain amino acid selected from isoleucine, leucine, and valine or a salt thereof, and a chemotherapeutic agent in combination.
(FR) La présente invention concerne un agent pour potentialiser l'activité antitumorale d'un agent chimiothérapique ciblant le cancer qui contient des cellules souches cancéreuses, comprenant au moins un acide aminé à chaîne ramifiée choisi parmi l'isoleucine, la leucine et la valine ou un de leurs sels. L'invention concerne également un agent pour traiter le cancer qui contient des cellules souches cancéreuses, comprenant au moins un acide aminé à chaîne ramifiée choisi parmi l'isoleucine, la leucine et la valine ou un de leurs sels, et un agent chimiothérapique combiné. L'invention concerne également un agent pour prévenir les métastases ou la récidive du cancer qui contient des cellules souches cancéreuses, comprenant au moins un acide aminé à chaîne ramifiée choisi parmi l'isoleucine, la leucine et la valine ou un de leurs sels, et un agent chimiothérapique combiné.
(JA)  本発明は、イソロイシン、ロイシンおよびバリンから選ばれる少なくとも一種の分岐鎖アミノ酸またはその塩を含む、癌幹細胞を含む癌に対する、化学療法剤の抗腫瘍活性を増強するための剤に関する。また、本発明は、イソロイシン、ロイシンおよびバリンから選ばれる少なくとも一種の分岐鎖アミノ酸またはその塩と、化学療法剤とを組み合わせてなる、癌幹細胞を含む癌を治療するための剤に関する。更に、本発明は、イソロイシン、ロイシンおよびバリンから選ばれる少なくとも一種の分岐鎖アミノ酸またはその塩と、化学療法剤とを組み合わせてなる、癌幹細胞を含む癌の転移または再発を予防するための剤に関する。
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