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1. (WO2012110860) TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/110860    International Application No.:    PCT/IB2011/054031
Publication Date: 23.08.2012 International Filing Date: 15.09.2011
IPC:
C07D 491/052 (2006.01), C07D 491/147 (2006.01), A61K 31/4164 (2006.01), A61P 29/00 (2006.01)
Applicants: GLENMARK PHARMACEUTICALS S.A. [CH/CH]; Chemin de la combeta 5, CH-2300 la chaux-de-fonds (CH) (For All Designated States Except US).
GHARAT, Laxmikant Atmaram [IN/IN]; (IN) (For US Only).
GAJERA, Jitendra Maganbhai [IN/IN]; (IN) (For US Only).
NARAYANA, Lakshminarayana [IN/IN]; (IN) (For US Only).
KHAIRATKAR-JOSHI, Neelima [IN/IN]; (IN) (For US Only).
KATTIGE, Vidya Ganapati [IN/IN]; (IN) (For US Only)
Inventors: GHARAT, Laxmikant Atmaram; (IN).
GAJERA, Jitendra Maganbhai; (IN).
NARAYANA, Lakshminarayana; (IN).
KHAIRATKAR-JOSHI, Neelima; (IN).
KATTIGE, Vidya Ganapati; (IN)
Priority Data:
61/446,587 25.02.2011 US
439/MUM/2011 17.02.2011 IN
Title (EN) TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS
(FR) COMPOSÉS TRICYCLIQUES EN TANT QU'INHIBITEURS DE MPGES-1
Abstract: front page image
(EN)The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase- 1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthama, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases. (I).
(FR)La présente invention concerne des composés tricycliques de formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci, en tant qu'inhibiteurs de mPGES-1. Ces composés sont des inhibiteurs de l'enzyme prostaglandine E synthase- 1 microsomale (mPGES-1) et sont, par conséquent, utiles dans le traitement de la douleur et/ou de l'inflammation provenant d'une variété de maladies ou d'états pathologiques, tels que l'asthme, l'arthrose, la polyarthrite rhumatoïde, la douleur aiguë ou chronique et des maladies neurodégénératives. (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)