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Machine translation
1. (WO2012110822) METHOD FOR IDENTIFYING NEONATES AT RISK FOR NECROTIZING ENTEROCOLITIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/110822    International Application No.:    PCT/GB2012/050353
Publication Date: 23.08.2012 International Filing Date: 16.02.2012
IPC:
C12Q 1/68 (2006.01)
Applicants: GENETIC ANALYSIS AS [NO/NO]; Pb 4239 Nydalen Oslo 0401 (NO) (For All Designated States Except US).
ROWE, Daniel [GB/GB]; (GB) (BB only).
Rudi, Knut [NO/NO]; (NO) (For US Only).
Vebø, Heidi Cecilie [NO/NO]; (NO) (For US Only).
Sekelja, Monika [NO/NO]; (NO) (For US Only).
Isaksen, Morten [NO/NO]; (NO) (For US Only)
Inventors: Rudi, Knut; (NO).
Vebø, Heidi Cecilie; (NO).
Sekelja, Monika; (NO).
Isaksen, Morten; (NO)
Agent: Dehns; St Bride's House 10 Salisbury Square London EC4Y 8JD (GB)
Priority Data:
1102693.7 16.02.2011 GB
Title (EN) METHOD FOR IDENTIFYING NEONATES AT RISK FOR NECROTIZING ENTEROCOLITIS
(FR) PROCÉDÉ POUR IDENTIFIER DES NOUVEAU-NÉS À RISQUE D'ENTÉROCOLITE NÉCROSANTE
Abstract: front page image
(EN)The invention provides a method for identifying a neonatal subject at risk for NEC, said method comprising (a) profiling the microbiota in a sample from the GI tract of said subject prior to a conclusive diagnosis of NEC and/or prior to full onset of NEC, (b1) comparing said profile to a standard microbiota profile obtained from corresponding samples from neonatal subjects with NEC or subjects which later developed NEC and determining the degree of correlation between said profile and the standard profile(s), and/or(b2) comparing said profile to a standard microbiota profile obtained from corresponding samples from neonatal subjects which did not develop NEC and determining the degree of correlation between said profile and the standard profile, and (c) identifying the subject as being at risk of NEC if significant correlation is observed in (b1) and/or significant correlation is not seen in (b2). An oligonucleotide probe set for use in the method of the invention, and kits containing the same, are also provided.
(FR)La présente invention concerne un procédé pour identifier un sujet nouveau-né à risque de NEC, ledit procédé comprenant (a) le profilage du microbiote dans un échantillon du tractus GI dudit sujet avant un diagnostic concluant de NEC et/ou avant l'apparition complète de NEC, (b1) la comparaison dudit profil à un profil de microbiote standard obtenu à partir d'échantillons correspondants de sujets nouveau-nés avec NEC ou des sujets qui développent ultérieurement NEC et la détermination du degré de corrélation entre ledit profil et le(s) profil(s) standard, et/ou(b2) la composition dudit profil à un profil de microbiote standard obtenu à partir d'échantillons correspondants de sujets nouveau-nés qui ne développent pas NEC et la détermination du degré de corrélation entre ledit profil et le profil standard, et (c) l'identification du sujet comme étant à risque de NEC si une corrélation significative est observée dans (b1) et/ou une corrélation significative n'est pas observée dans (b2). La présente invention concerne en outre une sonde oligonucléotidique pour utilisation dans le procédé de l'invention, et des kits contenant celle-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)