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1. (WO2012110200) CYCLIC PEPTIDE CYCLO (L -ARGINYL - GLYCYL - L -ASPARTYL - D - PHENYLALANYL - N-METHYL - L -VALYL), COMPOSITIONS THEREOF, AND USE THEREOF IN METHODS FOR TREATING GRAFT -VERSUS - HOST DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/110200    International Application No.:    PCT/EP2012/000436
Publication Date: 23.08.2012 International Filing Date: 01.02.2012
IPC:
A61K 38/12 (2006.01), A61P 37/06 (2006.01), A61P 29/00 (2006.01)
Applicants: MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250 64293 Darmstadt (DE) (For All Designated States Except US).
UNIVERSITAETSKLINIKUM FREIBURG [DE/DE]; Hugstetter Strasse 49 79106 Freiburg (DE) (For All Designated States Except US).
GOODMAN, Simon [GB/DE]; (DE) (For US Only).
DOTZAUER, Matthias [DE/DE]; (DE) (For US Only).
ZEISER, Robert Franz Karl [DE/DE]; (DE) (For US Only).
WEBER, Wolfgang Andreas [DE/DE]; (DE) (For US Only).
BEHE, Martin Peter [CH/DE]; (DE) (For US Only)
Inventors: GOODMAN, Simon; (DE).
DOTZAUER, Matthias; (DE).
ZEISER, Robert Franz Karl; (DE).
WEBER, Wolfgang Andreas; (DE).
BEHE, Martin Peter; (DE)
Priority Data:
61/444,303 18.02.2011 US
Title (EN) CYCLIC PEPTIDE CYCLO (L -ARGINYL - GLYCYL - L -ASPARTYL - D - PHENYLALANYL - N-METHYL - L -VALYL), COMPOSITIONS THEREOF, AND USE THEREOF IN METHODS FOR TREATING GRAFT -VERSUS - HOST DISEASE
(FR) PEPTIDE CYCLIQUE, CYCLO-(L‑ARGINYL-GLYCYL-L‑ASPARTYL-D‑PHÉNYLALANYL- N‑MÉTHYL-L‑VALYLE), COMPOSITIONS ASSOCIÉES ET UTILISATION DANS DES MÉTHODES DE TRAITEMENT DE LA MALADIE DU GREFFON CONTRE L'HÔTE
Abstract: front page image
(EN)The instant invention relates to compounds, compositions and methods are provided for prevention and treatment of various forms of graft-versus-host disease (GvHD) comprising or using Cilengitide, a cyclic arginine-glycine- aspartic acid containing pentapeptide, and/or pharmaceutically acceptable dervatives, solvates and/or salts thereof. Moreover, various dosing regimens and/or combinations comprising or using Cilengitide and/or pharmaceutically acceptable dervatives, solvates and/or salts thereof are provided, preferably for the treatment of humans in vivo and preferably as well for ex vivo conditioning of organ transplants in order to suppress immune responses and preferably also other adverse effects resulting in GvHD and related inflammatory processes.
(FR)La présente invention concerne des composés, des compositions et des méthodes destinés à la prévention et au traitement de diverses formes de la maladie du greffon contre l'hôte (GvHD) comprenant ou utilisant du cilengitide, un pentapeptide cyclique contenant de l'arginine-glycine-acide aspartique et/ou ses dérivés, solvates et/ou sels pharmaceutiquement acceptables. En outre, l'invention concerne des régimes d'administration des doses et/ou des combinaisons comprenant ou utilisant du cilengitide et/ou ses dérivés, solvates et/ou sels pharmaceutiquement acceptables, de préférence pour le traitement d'êtres humains in vivo et également de préférence pour un traitement ex vivo de greffes d'organes afin de réprimer les réponses immunitaires et aussi de préférence d'autres effets secondaires entraînant une GvHD et des processus inflammatoires associés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)